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Robert W. Gwadz, Ph.D.
Twinbrook III, Room 2W13
12735 Twinbrook Parkway
Rockville, MD 20892-8132
Phone: 301-496-6837
Fax: 301-402-2201
rgwadz@niaid.nih.gov

Tovi Lehmann, Ph.D.
tlehmann@niaid.nih.gov

Laboratory of Malaria and Vector Research

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Robert W. Gwadz, Ph.D.

Photo of Robert W. Gwadz, Ph.D.

Chief, International Studies of Malaria and Entomology Section, LMVR

Major Areas of Research

  • Antimalarial drugs
  • Malaria vaccines
  • Vector biology and malaria transmission
  • Training opportunities in Africa and Cambodia
 

Program Description

Research in the section explores broad population biology questions relevant to patterns of malaria transmission and vector control. Ecological, behavioral, genetic, and molecular approaches are used in our research. Studies are conducted at National Institutes of Health facilities in Rockville, Maryland, and at the Mali International Center for Excellence in Research (ICER) in Bamako, Mali. The Mali ICER is the result of NIAID’s long-term collaboration with Malian scientists and physicians at the National School of Medicine. The Mali ICER is now a well-equipped, highly productive program where research is led and executed by Malian staff.

Research at the Mali ICER is focused on malaria but also addresses other vector-borne diseases, such as leishmaniasis. This exceptional research center provides NIAID researchers with unique opportunities for field-lab studies. In our research projects, we seek discoveries that improve understanding of phenotypic diversity in vector species, its adaptive value, and epidemiological consequences.

Major research questions include

  • What are the forces underlying speciation in Anopheles gambiae, and what are the mechanisms producing reproductive isolation?
  • What factors determine susceptibility of vector populations to parasites?

Inquiries about predoctoral and postdoctoral fellowships are welcome.

Biography

Dr. Gwadz received his Ph.D. from the University of Notre Dame in 1970 for studies on the reproductive physiology of mosquitoes. He was a postdoctoral fellow in tropical public health at the Harvard University School of Public Health before joining NIH in 1972. He served as head of the Medical Entomology Program in the Laboratory of Parasitic Diseases until 1995. In LMVR, he is responsible for the development and operation of the Malaria Research and Training Center in Bamako, Mali, and the new LMVR malaria research program in Cambodia. In recognition of his work in establishing a program of cooperative research on vector-borne diseases in the Middle East, Dr. Gwadz was named an Honorary Fellow of the Hebrew University of Jerusalem, an Honorary Member of the Board of the Ain Shams University (Cairo) Center for Study of Tropical Diseases, and an Honorary Fellow of the Egyptian Society of Parasitologists.

Research Group

USA Mali
Dr. Abdoulaye Diabate
Dr. Jen Hume
Dr. Nicolas Manoukis (Ribeiro’s lab)
Mr. Rodrigo Gonzalez
Dr. Cecilia Coscaron
Mr. Andre Laughinghouse
Mr. Kevin Lee
Richard K. Sakai, Ph.D., Resident Scientist in Mali
Tovi Lehmann, Ph.D., Facility Chief
Mr. Adama Dao
Mr. Alpha Seydou Yaro
Mr. Abdoulaye Adamou
Mr. Moussa Diallo
Mr. Yaya Kassouge
Researcher setting up a transplantation cage
Abdoulaye setting up a larval transplantation cage near Bobo Dioulasso, Burkina Faso.
Researchers collecting mosquitoes
Adama (left) and Tovi (inside the bednet) during mosquito collection in a Malian village. (Adama caught most of the mosquitoes.)
 
Researchers filming mosquitoes
Moussa (left), Nick (center), and Alpha (right) about to set up their cameras to film mosquito swarms in Doneguebougo, Mali. Simultaneous filming with two cameras facilitates tracking mosquitoes in 3D.
Researchers setting up mosquito infection
Jen (right) and Rodrigo (left) setting up mosquito infection with Plasmodium gallinaceum.
 

Selected Publications

Diabaté A, Yaro AS, Dao A, Diallo M, Huestis DL, Lehmann T. Spatial distribution and male mating success of Anopheles gambiae swarms. BMC Evol Biol. 2011 Jun 28;11:184.

Huestis DL, Yaro AS, Traoré AI, Adamou A, Kassogué Y, Diallo M, Timbiné S, Dao A, Lehmann T. Variation in metabolic rate of Anopheles gambiae and A. arabiensis in a Sahelian village. J Exp Biol. 2011 Jul 15;214(Pt 14):2345-53.

Diabaté A, Dao A, Yaro AS, Adamou A, Gonzalez R, Manoukis NC, Traoré SF, Gwadz RW, Lehmann T. Spatial swarm segregation and reproductive isolation between the molecular forms of Anopheles gambiae. Proc Biol Sci. 2009 Dec 7;276(1676):4215-22.

Diabate A, Dabire RK, Heidenberger K, Crawford J, Lamp WO, Culler LE, Lehmann T. Evidence for divergent selection between the molecular forms of Anopheles gambiae: role of predation. BMC Evol Biol. 2008 Jan 11;8(1):5.

Yaro AS, Dao A, Adamou A, Crawford JE, Ribeiro JM, Gwadz R, Traoré SF, Lehmann T. The distribution of hatching time in Anopheles gambiae. Malar J. 2006 Mar 22;5:19.

Diabaté A, Dabire RK, Kengne P, Brengues C, Baldet T, Ouari A, Simard F, Lehmann T. Mixed swarms of the molecular M and S forms of Anopheles gambiae (Diptera: Culicidae) in sympatric area from Burkina Faso. J Med Entomol. 2006 May;43(3):480-3.

Visit PubMed for a complete publication listing for Dr. Gwadz, Dr. Sakai, or Dr. Lehmann.

Last Updated August 12, 2013