José M.C. Ribeiro, M.D., Ph.D.Twinbrook III, Room 2E3212735 Twinbrook ParkwayRockville, MD 20852-8132Phone: 301-496-9389Fax: email@example.com
Chief, Vector Biology Section, LMVR
Ixolaris, a novel TFPI molecule
Research in the Vector Biology Section explores the biochemical and pharmacological diversity found in the salivary glands of blood feeding insects and ticks. Molecular, biochemical, and pharmacological approaches are used in our research. Recently, we have used vector salivary gland transcriptome analysis to discover new and interesting compounds and for that reason have developed tools for bioinformatic analysis.
In each of the major areas of research, we seek discoveries that improve our basic knowledge of the evolution of the blood feeding behavior, at the same time generating novel compounds that can be of pharmacological use or developed as vaccine targets. Inquiries about predoctoral and postdoctoral fellowships as well as Ph.D. studentships in the NIH Graduate Partnership Program are welcome.
The figure shows the structure of Ixolaris, an anti-clotting protein derived from the tick Ixodes scapularis (also pictured). This protein has anti-clotting and anti-metastatic properties.
Dr. Ribeiro received his M.D. from the State University of Rio de Janeiro and a Ph.D. from the Biophysics Institute of the Federal University of Rio de Janeiro. He was an assistant and associate professor at the Harvard School of Public Health and professor at the department of entomology in the University of Arizona before joining NIAID in 1996. His work focuses on the role of vector saliva in blood feeding by arthropods, where a great diversity of pharmacologically active compounds and new targets for vaccination against vector-borne diseases have been uncovered. Dr. Ribeiro has served for many years in the Tropical Diseases Research Program of the World Health Organization (TDR/WHO) and as editor and reviewer for several journals.
Karim S, Singh P, Ribeiro JM. A deep insight into the sialotranscriptome of the gulf coast tick, Amblyomma maculatum. PLoS One. 2011;6(12):e28525.
Chagas AC, Calvo E, Pimenta PF, Ribeiro JM. An insight into the sialome of Simulium guianense (DIPTERA:SIMulIIDAE), the main vector of river blindness disease in Brazil. BMC Genomics. 2011 Dec 19;12:612.
Francischetti IM, Anderson JM, Manoukis N, Pham VM, Ribeiro JM. An insight into the sialotranscriptome and proteome of the coarse bontlegged tick, Hyalomma marginatum rufipes. J Proteomics. 2011 Nov 18;74(12):2892-908.
Alvarenga PH, Francischetti IM, Calvo E, Sá-Nunes A, Ribeiro JM, Andersen JF. The function and three-dimensional structure of a thromboxane A2/cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite. PLoS Biol. 2010 Nov 30;8(11):e1000547.
Ribeiro JM, Mans BJ, Arcà B. An insight into the sialome of blood-feeding Nematocera. Insect Biochem Mol Biol. 2010 Nov;40(11):767-84.
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Valenzuela JG, Belkaid Y, Kamhawi S, Sacks D, Ribeiro JMC, inventors; The United States of America as represented by the Secretary of the Department of Health and Human Services, assignee. Anti-arthropod vector vaccines, methods of selecting and uses thereof. United States patent US 7,964,576. 21 Jun 2011.
Valenzuela JG, Ribeiro JMC, Barral A, Netto M, Brodskyn C, Gomes R, inventors; The United States of America as represented by the Secretary of the Department of Health and Human Services, Cruz, assignees. Lutzomyia longipalpis polypeptides and methods of use. United States patent US 7,485,306. 3 Feb 2009.
Ribeiro JMC, Valenzuela JG, Charlab R, Mather TN, inventors; The United States of America as represented by the Department of Health and Human Services, University of Rhode Island, assignees. Ixodes salivary anticomplement protein. United States patent US 7,153,947. 26 Dec 2006.
Francischetti IMB, Valenzuela JG, Ribeiro JMC, inventors; The United States of America as represented by the Department of Health and Human Services, assignee. Ixodes scapularis tissue factor pathway inhibitor. United States patent US 7,078,508. 18 Jul 2006.
Cupp MS, Ribeiro JMC, Cupp EW, inventors; Auburn University, University of Arizona, assignees. Methods of use of recombinant vasoactive protein from salivary gland of the black fly. United States patent US 6,749,855. 15 Jun 2004.
Cupp MS, Ribeiro JMC, Cupp EW, inventors; Auburn University, The University of Arizona, assignees. Recombinant vasoactive protein from salivary gland of the black fly. United States patent US 6,500,420. 31 Dec 2002.
Visit the U.S. Patent and Trademark Office for a complete patent listing.
Last Updated November 01, 2012