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Laboratory of Parasitic Diseases

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Siddhartha Mahanty, M.D., M.P.H.

Photo of Siddhartha Mahanty, M.D., M.P.H.

Assistant Chief, Clinical Parasitology Section, LPD

Major Areas of Research

  • Clinical definition and pathogenesis underlying parasitic diseases
  • New methods of diagnosis of parasitic infections
  • Therapeutic interventions in parasitic infections
  • Hypereosinophilic syndromes (HES): from pathogenesis to novel therapeutic interventions
 

Program Description

The Clinical Parasitology Section is an interdisciplinary group of clinically trained LPD staff members who oversee the clinical research portfolio and provide clinical care, consultations, and training in tropical medicine and parasitology. The overriding goals of this program are

  • To gain insight into the clinical syndromes associated with parasitic infections
  • To understand and help define the pathogenesis underlying clinical disease
  • To identify better ways of treating individual infections and to prevent secondary consequences of treatment
  • To develop better diagnostic tools for the species-specific diagnosis of active parasitic infection

Although the Clinical Parasitology Section has protocols to see patients with any parasitic infection, the overwhelming majority of patients have neurocysticercosis, filarial infections (lymphatic filariasis, onchocerciasis, loiasis, mansonellosis), strongyloidiasis, hookworm infections, ascaraisis, giardiasis, echinococcosis, and leishmaniasis. We occasionally see patients with gnathostomiasis, African trypanosomiasis, Chagas disease, and malaria, among others.

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Biography

Dr. Mahanty received his M.B.B.S. from the University of New South Wales, Sydney, Australia, and training in internal medicine at the Australian National University, Canberra, Australia. He completed his fellowship in infectious diseases at the University of Oklahoma and Case Western Reserve University and postdoctoral training in parasitology and immunology in the Laboratory of Parasitic Diseases, NIAID. He is board-certified in internal medicine and infectious diseases. He also holds a diploma/certificate in tropical medicine and travelers’ health. He held faculty appointments at McGill University (Centre for Tropical Medicine) and the Centers for Disease Control and Prevention (CDC) in Atlanta before moving to NIH in 2003. Prior to joining the Laboratory of Parasitic Diseases in 2005, he was a staff clinician in the Malaria Vaccine Development Branch (now the Laboratory of Malaria and Vaccinology), where he oversaw the immunological evaluation of malaria vaccines and was principal investigator on several clinical trials. He is the author or co-author of more than 50 publications in the field of parasitology and immunology. In addition to a research interest in parasite, viral, and vaccine immunology, he has extensive clinical experience in tropical medicine and the conduct of research protocols.

Research Group

Photo of Clinical Parasitology Section Research Group
Seated (left to right): Amara Pabon, Amy Klion, Paneez Khoury, Kathryn Spates, Nicole Holland. Middle row: JeanAnne Ware Back Row (left to right): Ted Nash, Eunice Fox, Siddhartha Mahanty, Tom Nutman, Rojelio Mejia, Soumya Chatterjee.

Missing: Lauren Pauls, Jesica Christensen

Selected Publications

Nash TE, Garcia HH. Diagnosis and treatment of neurocysticercosis. Nat Rev Neurol. 2011 Sep 13;7(10):584-94.

Nash TE, Mahanty S, Garcia HH; Cysticercosis Group in Peru. Corticosteroid use in neurocysticercosis. Expert Rev Neurother. 2011 Aug;11(8):1175-83.

Stewart DM, Ramanathan R, Mahanty S, Fedorko DP, Janik JE, Morris JC. Disseminated Strongyloides stercoralis infection in HTLV-1-associated adult T-cell leukemia/lymphoma. Acta Haematol. 2011;126(2):63-7. Epub 2011 Apr 7.

Fink DL, Fahle GA, Fischer S, Fedorko DF, Nutman TB. Toward molecular parasitologic diagnosis: enhanced diagnostic sensitivity for filarial infections in mobile populations. J Clin Microbiol. 2011 Jan;49(1):42-7.

Ramanathan R, Talaat KR, Fedorko DP, Mahanty S, Nash TE. A species-specific approach to the use of non-antimony treatments for cutaneous leishmaniasis. Am J Trop Med Hyg. 2011 Jan;84(1):109-17.

Ogbogu PU, Bochner BS, Butterfield JH, Gleich GJ, Huss-Marp J, Kahn JE, Leiferman KM, Nutman TB, Pfab F, Ring J, Rothenberg ME, Roufosse F, Sajous MH, Sheikh J, Simon D, Simon HU, Stein ML, Wardlaw A, Weller PF, Klion AD. Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy. J Allergy Clin Immunol. 2009 Dec;124(6):1319-25.

Clinical Trials

Domestic (NIH Clinical Center, Bethesda, Maryland)

Parasitic Infections of the Gastrointestinal Tract, NCT00001162

Treatment of Patients With Cysticercosis With Praziquantel or Albendazole, NCT00001205

Host Response to Infection and Treatment in Filarial Diseases, NCT00001230

Activation and Function of Eosinophilia Conditions With Blood or Tissue Eosinophilia, NCT00001406

Evaluation, Treatment, and Monitoring of Patients With A Known or Suspected Parasitic Infections, NCT00001645

Brain Tissue Swelling and Seizure Activity in Inactive Cysticercosis, NCT00001912

Diagnosis and Treatment of Leishmanial Infections, NCT00344188

Imatinib Mesylate To Treat Myeloproliferative Hypereosinophilic Syndrome, NCT00044304

A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression, NCT00091871

Compassionate Use of Mepolizumab Treatment in Subjects with Hypereosinophilic Syndrome, NCT00244686

A Randomized, Placebo-Controlled, Double-Blind Pilot Study of Single-Dose Humanized Anti-IL5 Antibody (Reslizumab) for the Reduction of Eosinophilia Following Diethylcarbamazine Treatment of Loa loa Infection, NCT01111305

Miltefosine To Treat Mucocutaneous Leishmaniasis, NCT01050907

International

Host Response to Infection and Treatment in Lymphatic Filarial Disease in India, NCT00342576

Corticosteroids To Reduce Frequency of Seizures in Neurocysticercosis Patients, NCT00290823

Changes in HIV Viral Load in Patients Undergoing Treatment for Filarial Infection, NCT00344279

Medical Implications of Coinfection With Malaria and Filariasis Parasites, NCT00471666

Effect of Albendazole Dose on Treatment of Lymphatic Filariasis, NCT00511004

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Last Updated September 11, 2012

Last Reviewed September 11, 2012