David L. Sacks, Ph.D.
Chief, Intracellular Parasite Biology Section, LPD
Research in the Intracellular Parasite Biology Section (IPBS) focuses on the immunology and cell biology of leishmanial infections and the biology of Leishmania parasites within their mammalian hosts and sand-fly vectors. The research may have relevance to diseases, such as tuberculosis, caused by other intracellular pathogens or to other vector-borne diseases, such as malaria.
The IPBS is composed of an interdisciplinary group of immunologists, cell biologists, and entomologists conducting basic and translational research aimed at the following:
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Dr. Sacks obtained his Ph.D. from Harvard University for studies on immune responses to chlamydial infections. Following a postdoctoral fellowship at the National Institute for Medical Research in London (Mill Hill) studying immune suppression in African trypanosomiasis, he joined the Laboratory of Parasitic Diseases in 1980. He became a senior investigator in 1986.
Sacks DL. Vaccines against tropical parasitic diseases: a persisting answer to a persisting problem. Nat Immunol. 2014 May;15(5):403-5.
Inbar E, Akopyants NS, Charmoy M, Romano A, Lawyer P, Elnaiem DE, Kauffmann F, Barhoumi M, Grigg M, Owens K, Fay M, Dobson DE, Shaik J, Beverley SM, Sacks D. The mating competence of geographically diverse Leishmania major strains in their natural and unnatural sand fly vectors. PLoS Genet. 2013;9(7):e1003672.
Gautam S, Kumar R, Maurya R, Nylén S, Ansari N, Rai M, Sundar S, Sacks D. IL-10 neutralization promotes parasite clearance in splenic aspirate cells from patients with visceral leishmaniasis. J Infect Dis. 2011 Oct;204(7):1134-7.
Peters NC, Kimblin N, Secundino N, Kamhawi S, Lawyer P, Sacks DL. Vector transmission of leishmania abrogates vaccine-induced protective immunity. Plos Pathog. 2009 Jun;5(6):e1000484.
Akopyants NS, Kimblin N, Secundino N, Patrick R, Peters N, Lawyer P, Dobson DE, Beverley SM, Sacks DL. Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector. Science. 2009 Apr 10;324(5924):265-8.
Peters NC, Egen JG, Secundino N, Debrabant A, Kimblin N, Kamhawi S, Lawyer P, Fay MP, Germain RN, Sacks D. In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies. Science. 2008 Aug 15;321(5891):970-4.
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Last Updated June 12, 2014