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Laboratory of Persistent Viral Diseases

Bruce W. Chesebro, M.D., Chief

The Laboratory of Persistent Viral Diseases (LPVD) studies persistent active or latent viral or prion disease infections. Investigators place particular emphasis on persistent infections of the nervous system and of the hematopoietic and lymphoid systems. The laboratory is also studying the roles of persistent infection in the development of retrovirus-induced immunosuppression. Models being examined include prion diseases of various species, murine and human retroviruses.

The major research goals of the laboratory are to understand basic pathogenic mechanisms induced by these infections, to study immune or other defense mechanisms used by infected individuals against infections, and to develop drug therapies capable of reducing or eliminating such infections.

Sections and Units

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Major Areas of Research

  • Study of the nature of the transmissible agent responsible for prion diseases
  • Study of the pathogenesis of prion diseases using biochemical, cell culture, and animal model methods
  • Development of drug therapies for prion diseases
  • Characterization of mechanisms of pathogenesis, immunosuppression, and immunity of retroviral infection in animals and humans with particular reference to infections involving hematopoietic cells and brain cells
  • Study of genetic control of host defense mechanisms against retroviral diseases, including central nervous system disease and leukemia
  • Study of diseases associated with expression of endogenous retroviruses or recombinant retroviruses

Last Updated February 05, 2016