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Laboratory of Systems Biology

m=microRNA; T=target; U=common regulator By integrating genomics and expression data, we inferred that tightly coupled circuits involving microRNA and their target(s) are highly prevalent in the human and mouse genomes. The prevalence of “incoherent” circuits is especially intriguing and suggests that microRNAs likely play homeostatic, noise-buffering, and fine-tuning roles in diverse contexts.


MicroRNA co-targeting network inferred by mirBridge. A majority of microRNAs co-target with a few “hub” microRNAs (yellow nodes on the left). Clique-like structures (some containing micro RNAs with known shared functions) are apparent (above), suggesting that multiple microRNAs tend to work together to perform specific functions.

Last Updated August 17, 2011