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Contact Info

Dr. Malla Rao
Deputy Branch Chief
Parasitology and International Programs Branch
Email: mrao@niaid.nih.gov

International Centers of Excellence for Malaria Research (ICEMR)

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Southeast Asia Malaria Research Center

Dr. Liwang Cui
Dr. Liwang Cui, PI for the Southeast Asia ICEMR.

 

Principal Investigator: Liwang Cui, Ph.D.
Lead Institution: Pennsylvania State University, University Park
For more information, please visit the ICEMR's website at ICEMR Southeast Asia Malaria Research Center

Project Leads

  • Jetsumon Sattabongkot – Leader, Mahidol University; Ying Wang – Co-leader, Third Military Medical University; Jeraphat Sirichaisinthop, Vector Borne Disease Research Center, Saraburi, Thailand
  • Guiyan Yan – Leader, University of California, Irvine
  • Liwang Cui – Leader, Pennsylvania State University; Xin Zhuan Su – Co-leader, NIAID/NIH; Zhaoqing Yang – Co-Leader, Kunming Medical University
  • Baomin Wang – Leader, China Agricultural University; Liwang Cui – Co-leader, Pennsylvania State University

Collaborating Institutions

  • China Agricultural University, Beijing, China
  • Chulalongkom University, Bangkok, Thailand
  • Dalian Institute of Technology, Dalian, China
  • Department of Medical Research, Yangon, Myanmar
  • KR2 Hospital, Laiza, Kachin, Myanmar
  • Kunming Medical University, Yunnan Province, China
  • Mahidol University, Bangkok, Thailand
  • Nanjing Medical University, Nanjing, Jiangsu, China
  • Third Military Medical University, Chongqing, China
  • Vector Borne Disease Research Center, Saraburi, Thailand

Research Areas

The central goal of the Southeast Asia ICEMR is to improve understanding of malaria epidemiology and vector systems and their roles in malaria transmission. The research team will also examine the mechanisms of drug resistance in parasites so that more effective, integrated malaria control can be achieved through a combination of accurate surveillance of the disease, integrated vector control, and more effective treatments in Southeast Asia.

Regional Impact

Southeast Asia accounts for 30 percent of global malaria morbidity and 8 percent of global mortality. The regional ICEMR will bring together diverse expertise from the United States, China, and Thailand to address urgent problems that are relevant to both regional and global malaria control.


View Associated sites in China (Anhui Province, Guanxi Province, Yunan Province), Thailand (Sa Kaeo, Mae Sod), Myanmar (Kachin State, Shan State) in a larger map

Map description: Associated sites in China (Anhui Province, Guanxi Province, Yunan Province), Thailand (Sa Kaeo, Mae Sod), Myanmar (Kachin State, Shan State)

Accomplishments

  • Accurate malaria epidemiological study at the China-Myanmar and Thailand-Myanmar border areas
  • Investigation of malaria epidemiology associated with internally displaced populations in Myanmar
  • Detailed insecticide resistance study of major malaria vector species
  • Establishment of archived parasite samples for the elucidation of drug resistance mechanisms with a focus on artemisinin
  • Development of monoclonal antibodies against artemisinin derivatives and serological detection methods (ELISA and dipsticks)

Selected Publications

  1. Yuan L, Zhao H, Wu L, Li X, Parker D, Xu S, Zhao Y, Feng G, Wang Y, Yan G, Fan Q, Yang Z, Cui L. 2013. Plasmodium falciparum populations from northeastern Myanmar display high levels of genetic diversity at multiple antigenic loci. Acta Trop. 125 53– 59. PMID: 23000544
  2. Zhong D, Chang X, Zhou G, He Z, Fu F, Yan Z, Zhu G, Xu T, Bonizzoni M, Wang M.-H, Cui L, Zheng B, Chen B, Yan G. 2013. Pyrethroid resistance in the Asian malaria vector Anopheles sinensis: Varying importance of kdr and metabolic detoxification mechanisms across central and southern China. PLoS One 8, e55475. PMID: 23405157
  3. Miao M, Wang Z, Yang Z, Yuan L, Parker DM, Putaporntip C, Jongwutiwes S, Xangsayarath P, Pongvongsa T, Moji H, Tuong TD, Abe T, Nakazawa S, Myat Phone Kyaw, Yan G, Sirichaisinthop J, Sattabongkot J, Mu J, Su X-Z., Kaneko O, Cui L. 2013. Genetic diversity and lack of artemisinin selection signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion. PLoS One 8, e59192. PMID: 23555629
  4. Cui L, Wang, Z, Miao J, Miao M, Chandra R, Jiang H, Su X,Cui L. 2012. Mechanisms of in vitro resistance to dihydroartemisinin in Plasmodium falciparum. Mol. Microbiol. 86, 111–128. PMID: 22812578

Featured Research

Last Updated October 17, 2014