| NB: Concepts represent early planning stages for PAs, RFAs, or RFPs for Council 's input. Council approval does not guarantee that a concept will become an initiative.
If NIAID publishes an initiative from one of these concepts, we link to it below. For a full list of initiatives, go to NIH Funding Opportunities Relevant to NIAID.
Table of Contents
Global HIV/AIDS Vaccine
Enterprise Secretariat
Request for Proposals Contact: Elizabeth Shanahan
Phone: 301-594-6309
Internet: eshanahan@niaid.nih.gov
Objective: The goal of this initiative is to accelerate the discovery
of an HIV/AIDS vaccine through support of the Global HIV/AIDS Vaccine
Enterprise (GHAVE) Secretariat. GHAVE is a unique international organization
designated
by GHAVE partners to coordinate efforts to accomplish the GHAVE Scientific
Strategic Plan, facilitate the use of common tools and technologies,
and ensure access to optimized resources in a transparent, cooperative,
and collaborative manner.
Description: The Global HIV/AIDS Vaccine Enterprise is an alliance
of independent entities acting as partners to accelerate the development
of a preventive vaccine for HIV. The goal of this initiative is to support
the mission of GHAVE, facilitated through the Enterprise Secretariat
whose core functions are scientific stewardship, communication and knowledge
management, and policy analysis and development. To promote the mission
of NIAID/DAIDS this initiative will focus specifically on the first two
functions - namely scientific stewardship and communication and knowledge
management.
The specific responsibilities of the Secretariat will be to: (1) update
the GHAVE Scientific Strategic Plan (SSP) through a global consultative
process; (2) plan and organize meetings (expert working groups, advisory
committees, and other meetings) to stimulate interaction among various
stakeholders, particularly the scientific community, and obtain input
necessary to update and revise the SSP; and (3) generate meeting summaries,
transcripts, and reports and make them widely available, including through
a Web site,
to ensure global access to new scientific information and scientific
priorities.
Women's HIV Interdisciplinary Network II
For the published initiative, see the January
31, 2007, Guide announcement, HIV Interdisciplinary Network
for Pathogenesis Research in Women (U19).
Request for Applications
Contact: Nabila Wassef
Phone: 301-435-3751
Internet: nwassef@niaid.nih.gov
Objective: To expand knowledge of the pathogenesis of HIV infection
in women and to investigate gender-specific biologic factors that impact
HIV-1 transmission, disease acquisition, and disease manifestations in
women.
Description: This RFA seeks to expand the research program on
HIV pathogenesis in women initiated by WHIN. Applicants are sought to
pursue research that addresses gender differences in one or more of the
following areas: 1) immunology, 2) pharmacology, 3) response to therapy,
4) complications of therapy, 5) immunology, virology, genetics, behavior
of transmission, and 6) health care utilization.
NIAID seeks to develop an environment where WHIN investigators strengthen
collaborations within the WHIN research network and with other NIAID-sponsored
programs and cohorts. To facilitate this, the WHIN will hold semi-annual
scientific meetings in conjunction with or in collaboration
with other sponsored groups. For example, meetings between the WHIN and
existing cohorts of women and appropriate controls, especially the Women's
Interagency HIV Study (WIHS), would provide greater knowledge of scientific
opportunities to collaborate. Such cohort studies have substantial specimen
repositories and longitudinal data of disease outcomes that are available
for collaborative studies. In addition, there are mechanisms within
NIAID observational cohort studies for enhanced
specimen
collection.
Women's
Interagency HIV Study
For the published initiative, see the December
27, 2006, Guide announcement.
Request for Applications
Contact: Gerald Sharp
Phone: 301-451-2573
Internet: gsharp@niaid.nih.gov
Objective: The objective of this RFA is the continuation
of the WIHS and the WIHS Data Management and Analysis Center (WDMAC)
to pursue further investigations of HIV disease in women in the United
States.
Description: This initiative will support the continuation of
the WIHS, the largest cohort study of HIV/AIDS in women in the U.S. It
will support the six NIAID-supported WIHS clinical sites and the Statistical
and Data Analysis Center.
HIV
Database and Analysis Unit
Request for Proposals
Contact: Nancy Hershey
Phone: 301-496-0193
Internet: nhershey@niaid.nih.gov
Objective: The objective of the HIV Database and Analysis Unit
is to continue the well established centralized resource for
compilation and analysis of genetic sequences,
immunological
epitopes, and associated data for HIV-1 and related lentiviruses, together
with results from non-human primate vaccine and adjuvant studies. The
information is widely disseminated to the scientific community in a timely
fashion to assist with vaccine design and development.
Description: This initiative will continue support for an HIV
Database and Analysis Unit for the compilation, analysis, and dissemination
of HIV genetic sequence and associated data. Data that is collected includes
nucleotide sequences of HIV-1 and related lentiviruses, along with
associated biological and immunological data, published results from
nonhuman primate vaccine studies, and information and data on novel adjuvants.
Analysis of this data yields nucleotide alignments, amino acid sequences
and alignments, classification of virus isolates both at the nucleotide
and amino acid level, analysis of protein glycosylation patterns, molecular
epidemiological data about the spread of the viruses as well as their
mutation rate and evolution. Immunological data, including cytotoxic
T-cell epitopes, helper T-cell epitopes, and neutralization epitopes,
is also compiled and integrated with genetic sequence data. Separate
databases compile nonhuman primate vaccine study results and information
on vaccine adjuvants. Information gathered through this database is made
available through an Internet web site and by direct mailing of compiled
data to all interested investigators in the form of annual compendia.
Integrated
Preclinical/Clinical Program for HIV Topical Microbicides
For the published initiative, see the March 4, 2008, Guide announcement.
Request for Applications
Contact: Jim Turpin
Phone: 301-451-2732
Internet: jt335x@nih.gov
Objective: The purpose of the Integrated Preclinical/Clinical
Program in HIV Topical Microbicides (IPCP-HTM) is: (1) to stimulate a
strong and diverse base in preclinical discovery and development of new
microbicide/combination strategies for vaginal or rectal use; and (2)
to support translation of new microbicide/combination strategies from
preclinical studies to pilot clinical studies.
Description: This RFA will support multiproject, multi-disciplinary
research groups whose goal is to advance microbicide/combination strategies
from preclinical to clinical studies. A microbicide/combination strategy
with multiple components may include more than one agent that specifically
inhibits HIV transmission and replication by diverse mechanisms, formulations
that provide a physical barrier effect, delivery of single microbicides
in formulations that optimize excipient anti-HIV activity, and/or agents
that confer mucosal protection locally such as genetically engineered
lactobacillus. As part of an integrated approach to the critical path
development of a specific candidate product and advancement into a pilot
clinical trial, research in the area of formulation science and development
of new and/or improved in vitro (e.g., tissue explants) and in
vivo models
for evaluating the safety and efficacy of new microbicides may be included.
The involvement of the private sector will be strongly encouraged.
DAIDS
Research Support Services Contract
Request for Proposals
Contact: Josh LaVine
Phone: FedVRS 866-410-5787 ext. 59981,
TTY 301-496-2509
Internet: jlavine@niaid.nih.gov
Objective: This initiative will provide funding for critical
services to support research management activities of the Division of
AIDS (DAIDS). Specifically a contract will be awarded to provide services
in the following areas: (1) administrative, technical, and logistical
support for scientific meetings, workshops, and conferences, (2) preparation
of scientific and technical reports, and (3) other research management
support services such as taking minutes for meetings, preparing summaries,
and providing necessary supplies and equipment.
Description: The contract will provide continued support for
important aspects of research management and operations for the DAIDS.
This will include conference and logistical management support, document
preparation, and other management support tasks. Examples of
the types of meetings include meetings of the AIDS Research Advisory
Committee (3 times a year); Data Safety Monitoring Boards (>6 a
year), AIDS Vaccine Research Working Group (2 times a year, with one
international), and a variety of DAIDS-sponsored scientific
workshops and other meetings with collaborators and other stakeholders.
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