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The Many Hosts of Mycobacteria V
Advancing Translational Science

A Comparative Mycobacteriology Symposium
July 16–17, 2012

Day 1 of the workshop will examine “Cause and Effect” of mycobacterial infections

Session I will explore pathology across species, including persistence, chronic and latent disease, and host/pathogen variability

  • Dynamics of the pathological lesions (granulomas and disseminated disease)
  • What factors are at play when disease is sub-clinical or chronic; how does this affect active disease or disease resolution; what models described this best?
  • Why do different host genetic backgrounds respond differently to the same pathogen?
  • Why does the same pathogen produce different disease in different species of hosts?
  • Why do genetically different pathogens produce different pathology in the same host?
  • Can genetically diverse mouse strains be used to dissect the contribution of host diversity for mycobacterial infections as a whole?
  • How do relevant co-infections affect pathogenicity, and can this be studies in natural versus experimental infection?

Session II will evaluate animal models in current use for testing of drugs and vaccines

  • What are the currently used protocols modeling and how can they be interpreted with regard to human TB; what endpoints do these protocols measure for tuberculosis that can be translated to human disease?
  • Is it feasible/rational to use one model for both drugs and vaccines?

Day 2 of the workshop will provide an in-depth discussion of currently available or needed “Tools” for research. Discussion will also include a summary of NIAID funding opportunities, preclinical services, bioinformatics and sequencing services as well as Biochemical Reagents. This will be an opportunity for the community to provide input into services that are needed to help advance key research directions in mycobacterial infections/disease.  

Last Updated April 24, 2012

Last Reviewed April 24, 2012