FOR IMMEDIATE RELEASE
Thursday, Oct. 11, 2007
NIAID MEDIA AVAILABILITY
Quick Technique to Identify Adenoviruses Can Improve Patient Care
Grantees of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have adapted a rapid and accurate new molecular typing strategy and used it to conduct one of the most comprehensive studies of adenoviruses ever performed in the United States. Adenoviruses commonly cause respiratory illnesses and infections of the stomach, intestine, eyes and bladder. Sometimes they cause epidemics and deaths. The new findings, from the extensive adenovirus epidemiological data collected in the United States, reveal that adenoviruses are frequently associated with hospitalizations and that some of these viruses may cause more severe disease than others.
The new gene sequencing strategy, first developed by researchers at the U.S. Centers for Disease Control and Prevention, identifies the adenovirus type in two days compared with the previous method that took weeks. The method’s speed will help public health officials better understand adenovirus outbreaks in communities and other settings where people are in close contact, such as hospitals and long-term care facilities. It also will help clinicians know what type is causing the infection in order to use the appropriate antiviral treatment. Some adenovirus strains, particularly those considered as emerging pathogens, are more often associated with severe disease and death.
In an effort to better understand how adenovirus infection is caused and spread in different settings and populations, Gregory Gray, M.D., of the University of Iowa, and his colleagues analyzed clinical adenovirus-positive samples and patient data from 22 military and civilian medical facilities over a 25-month period. They characterized the strains of 2,237 adenovirus-positive specimens and compared their sequences with those of the 51 recognized strains that infect humans.
Highlights of their findings include the following:
Researchers say quickly recognizing the adenovirus type is key to starting the appropriate antiviral therapy, controlling outbreaks and understanding the association of adenoviruses with a number of chronic disease conditions. Dr. Gray and his colleagues are using the molecular typing technique to help clinicians do just that.
Catherine Laughlin, Ph.D., Chief, Virology Branch, Division of Microbiology and Infectious Diseases, NIAID
Eun-Chung Park, Ph.D., Program Officer, Virology Branch, Division of Microbiology and Infectious Diseases, NIAID
NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of
infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News
releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at www.niaid.nih.gov.
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S.
Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research,
and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
NIH...Turning Discovery Into Health ®
back to top
Last Updated October 11, 2007