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National Institute of Allergy and
Infectious Diseases (NIAID)
http://www.niaid.nih.gov

FOR IMMEDIATE RELEASE
Thursday, Aug. 9, 2007

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NIAID MEDIA AVAILABILITY
New Contracts Support Clinical Trials on Antibiotic-Resistant, Community-Acquired Staph Infections

What:

Finding ways to effectively treat bacterial infections with antibiotics that minimize the development of drug resistance is a key goal of antimicrobial resistance research supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. NIAID today announced the award of two new five-year contracts to study whether selected oral, off-patent antibiotics can effectively treat uncomplicated cases of skin and soft tissue infections caused by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) bacteria. If so, doctors could use those antibiotics first in an effort to dampen the development of resistance to such last-resort antibiotics as vancomycin.

S. aureus bacteria are the most common cause of skin and soft tissue infections in the United States; strains resistant to the antibiotic methicillin have increased and are now common in hospitals and long-term care facilities. The emergence of CA-MRSA in the 1990s caused great concern to health professionals because, unlike hospital-acquired infections, CA-MRSA affects otherwise healthy people who have not recently been hospitalized or exposed to other medical facilities. CA-MRSA illnesses range from minor skin and soft tissue infections to serious or even lethal infections. The best ways to treat CA-MRSA have not yet been determined.

Hospital-acquired MRSA infections generally respond only to a few antibiotics such as vancomycin and linezolid. Lab tests suggest that CA-MRSA bacteria are susceptible to more antibiotics than hospital-acquired MRSA strains, but the clinical efficacy of these antibiotics in treating CA-MRSA has not been proven.

The newly awarded contracts will support multisite, Phase II/III clinical trials to determine better ways to treat skin and soft tissue infection caused by CA-MRSA with the aim of preserving the efficacy of final-option drugs such as vancomycin and linezolid by reducing their frequency of use. Because the antibiotics used in the trial, which include clindamycin and trimethoprim/sulfamethoxazole, are no longer under patent, pharmaceutical companies have no incentive to conduct clinical trials using them. By supporting clinical trials of off-patent antibiotics, NIAID plays a key role in ensuring that the value of these drugs is fully realized.

One study will be led by University of California, Los Angeles, researchers David A. Talan, M.D., and Gregory J. Moran, M.D. The second contract was awarded to the University of California, San Francisco, where Henry F. Chambers, M.D., will lead the study. Each trial is designed to enroll up to 1,200 people. Together, the two contracts will total up to $19 million over five years.

Spokespersons: Anthony S. Fauci, M.D., NIAID Director; Dennis M. Dixon, Ph.D., Chief, Bacteriology and Mycology Branch, NIAID Division of Microbiology and Infectious Diseases
Contact: To schedule an interview, contact Anne A. Oplinger in the News and Public Information Branch at 301-402-1663 or aoplinger@niaid.nih.gov.
Resource: For more information, see NIAID’s antimicrobial resistance and MRSA research program.

NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at www.niaid.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

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Last Updated August 09, 2007