FOR IMMEDIATE RELEASE
Tuesday, Oct. 19, 2010
“Many infectious diseases are increasingly difficult to treat because bacteria and other microbes have developed resistance to commonly used antimicrobial drugs,” says NIAID Director Anthony S. Fauci, M.D. “Research to preserve the effectiveness of licensed antibiotics is a critical priority for the Institute. With these new contracts, NIAID now supports a total of eight large clinical trials in this arena.”
Antimicrobial research has changed significantly since many current drugs were developed, says Dennis M. Dixon, Ph.D., chief of NIAID’s Bacteriology and Mycology Branch. “Years ago, we were not as focused on antimicrobial resistance because there was generally another class of drug in the research and development pipeline. Today, the development of new antimicrobials is moving much more slowly than the evolution of resistance to existing treatments, so we need to preserve the drugs we have.”
These new trials are part of a two-pronged NIAID approach to antimicrobial research: learning how to make better use of the drugs we have today in order to protect their usefulness while simultaneously facilitating the development of new drugs.
Like the four large NIAID trials already in progress, the four new studies are designed to answer specific questions about how to improve treatment strategies. The investigators will conduct clinical trials of new regimens involving the use of already licensed, off-patent antimicrobial therapies to reduce the risk of antimicrobial resistance developing in the diseases of interest. For example, the dosage and duration of treatment will be evaluated.
“If one type of treatment proves to be just as safe and just as effective as one that is traditionally used, but less likely to induce antimicrobial resistance, then the new treatment could be preserved for a longer time,” says Dr. Dixon. “These clinical trials look not only at effectiveness of various antimicrobial drugs in the individual patient, but also at how to preserve the most effective use of drugs in the overall population. The goal is to be more precise with what antimicrobial drugs a patient needs, at what dose, and for how long.”
The awardees of the four new contracts include:
For more information on antimicrobial resistance, visit NIAID’s Antimicrobial Resistance Web portal.
For more information on this set of contracts, see the announcements for the 2007 awards and the 2009 awards.
NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of
infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News
releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at www.niaid.nih.gov.
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S.
Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research,
and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
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Last Updated October 19, 2010
Last Reviewed October 19, 2010