See the Glossary for more terms.
Concepts represent early planning stages for program announcements, request for applications, or solicitations for Council's input. If NIAID publishes an initiative from one of these concepts, we link to it below. To find initiatives, go to the Opportunities and Announcements portal.
NB: Council approval does not guarantee that a concept will become an initiative.
For the published request for applications, see the November 5, 2012, Guide announcement.
For the published requests for applications, see the January 15, 2013, Guide announcements, Autoimmunity Centers of Excellence, Clinical Research Program and Autoimmunity Centers of Excellence, Basic Research Program.
Request for Applications
Contact: Nancy Bridges
Objective: This initiative will support clinical trials in organ or cellular transplantation with associated studies of immune mechanism. The goal of this research is to improve the outcome of organ transplantation by (1) evaluating innovative therapies that will increase graft survival without medication-induced injury; (2) identifying and validating biomarkers of immune activation, immune quiescence, and pending graft injury in urine, blood, or tissue biopsies that will allow individualization and optimization of anti-rejection therapy; and (3) increasing our understanding of the mechanisms underlying allograft rejection and injury.
Description: This initiative will support multicenter clinical trials with associated studies of immune mechanism in heart, lung, kidney, liver, and intestinal transplantation. Clinical trials of nonhematopoietic cellular transplantation as replacement therapies are included, as are those of transplantation of bone marrow or mesenchymal stem cells, or of immunologically active cells as adjuncts to organ transplantation. Studies of hematopoietic cell transplantation and of pancreatic islet transplantation are excluded.
This is a renewal of RFA-AI-08-015; the inclusion of cellular therapies is an expansion of that RFA.
For the published broad agency announcement, see the May 10, 2013, solicitation.
Contact: Alkis Togias
Last Updated May 13, 2013
Last Reviewed February 15, 2012