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June 2013 DAIT Council-Approved Concepts

Concepts represent early planning stages for program announcements, requests for applications, or solicitations for Council's input. If NIAID publishes an initiative from one of these concepts, we link to it below. To find initiatives, go to the Opportunities and Announcements portal.

NB: Council approval does not guarantee that a concept will become an initiative.

Table of Contents

Immunobiology of Xenotransplantation

Request for Applications

Contact: Nasrin Nabavi

Objective: To develop preclinical porcine to nonhuman primate models of islet, kidney, heart, lung, or liver xenotransplantation. The goals of this program are to:

  1. Delineate the cellular and molecular mechanisms of xenograft rejection and the induction of tolerance.
  2. Develop effective strategies to improve xenograft survival.
  3. Characterize the physiological compatibility and limitations of xenografts.

The long-term goal of this program is to develop novel and effective strategies for applying xenotransplantation in the clinic.

Description: This initiative will support new or competing renewal proposals focused on:

  1. Developing or optimizing models of porcine to nonhuman primate xenotransplantation of islet, kidney, heart, lung, or liver.
  2. Defining and ultimately resolving the physiological and immunological barriers of successful xenograft application in clinic.

No changes are anticipated from the previous solicitation.

Resources to Assist Investigations in Primary Immunodeficiency Diseases

For the published request for applications, see the December 11, 2013, Guide announcement.

Development of Sample Sparing Assays for Monitoring Immune Responses

Request for Applications

Contact: Kasia Bourcier

Objective: To accelerate developing sample sparing assays that will broaden availability of well-characterized tools for monitoring immune responses in healthy individuals as well as in disease conditions such as allergy, asthma, autoimmunity, primary immunodeficiency, transplantation, and infection.

Description: This program will solicit applications with the potential to support immunological research to develop innovative and validated sample sparing assays that lead to the maximum use of the sampled material and/or increased sensitivity and specificity of the existing assay. Assays that will be supported could include novel approaches for monitoring antigen-specific responses and various cell populations, assessments of T and B regulatory networks, cytokine and signaling networks, gene function/expression studies, and proteomics. Techniques that integrate multiple measurements are especially valuable for a sample sparing concept and will be encouraged.

Last Updated December 12, 2013

Last Reviewed June 12, 2013