We moved the contents of this article into Ten Steps to a Winning R01 Application. As part of the Strategy for NIH Funding, the ten steps give you a path to funding success if you're applying for an R01.
Really. After getting several requests, we took your advice and expanded the outline of our Ten Steps to a Winning R01 Application to bring in the bi-weekly articles that narrate each step.
The outline and all articles are now bundled together in one tidy package—and we'll add the last one when the series ends with our March 28 issue.
We hear that some of you find this resource useful for both teaching and learning purposes. Everything we publish in the public domain, so you may repurpose the content as you wish.
Not to forget: our Strategy for NIH Funding gives you additional advice and resources, such as Strategy Timelines that show your time-sensitive actions for a given stage.
For example, when applying for a grant, follow the Timing for Submitting Your Application page so you avoid painful situations like failing to verify that your application made it through the Commons and finding out too late that it did not. Ouch!
February was a busy month for funding opportunity announcements seeking research on different aspects of HIV. Here's a brief look at each.
Note: Except for the first one listed below, all FOAs are for R01s.
Better hurry if you want to apply for this opportunity, which seeks innovative, high-risk research on tools and strategies for eradicating latent reservoirs of HIV. This year's application deadline is April 25, 2012, with optional letters of intent due March 25. The next application due dates are April 25 of 2013 and 2014.
Unlike the other featured FOAs, this one is a phased innovation award (R21/R33), which covers two phases with little or no funding gap between phases. To learn more, see our R21/R33 Phased Innovation Award SOP.
Check the February 17, 2012, Guide notice for more information.
While we're on the topic of HIV reservoirs, consider applying for this FOA if you can propose ways to eliminate residual reservoirs of HIV that persist despite the use of traditional antiretroviral therapy to suppress plasma viremia.
The objective here is to develop innovative strategies for delivering antiretroviral drugs and other anti-HIV agents to specific cell types or tissue compartments that serve as persistent HIV-producing reservoirs.
Learn more in the February 15, 2012, Guide notice.
You may want to apply if your research can boost understanding of how to generate effective and persistent T lymphocyte responses against infection by HIV or other mucosal pathogens in the female reproductive tract.
Read the February 14, 2012, Guide notice for full details.
The goal of this opportunity: to stimulate novel areas of research on the role of glycosylation in HIV-1 envelope protein immunogenicity and modulation of the immune response to HIV viral infection.
To effectively carry out proposed research in this area, NIAID encourages collaboration among glycobiologists, virologists, immunologists, biochemists, clinical scientists, carbohydrate chemists, and other relevant specialists.
Find more information in the February 14, 2012, Guide notice.
This PA is for you if your project can further our understanding of the interaction of genital (female and male) and gastrointestinal tract mucosal tissue with non-vaccine biomedical prevention candidates and strategies.
Get the full scoop in the February 14, 2012, Guide notice.
Researchers focused on the health of lesbian, gay, bisexual, transgender, and intersex (LGBTI) populations should check out a trio of new funding opportunities.
NIH reissued three program announcements (PAs)—an R01, R03, and R21—that seek research on the biological, clinical, behavioral, and social processes that affect the health and development of LGBTI populations and their families.
To fill research gaps identified in an Institute of Medicine (IOM) report, the PAs seek projects that will:
For complete details, including research areas of interest, read the R01, R03, and R21 PAs.
NIH encourages interested applicants to read the IOM report The Health of Lesbian, Gay, Bisexual, and Transgender People: Building a Foundation for Better Understanding.
Have you used the RePORT Web site to find data on NIH research activities? If not, here are a few uses for RePORT we think you’ll like.
If you're looking for the percentage of reviewed applications that received funding, you can query the success rate data and narrow results by institute and funding year. For example, see Research Project Success Rates for NIAID in 2011.
You can also access various databases from RePORT, such as the NIH Intramural Database to view intramural research or PubMed for journal articles. Or find more systems, such as iEdison.
One tool on the site, called RePORTER (RePORT Expenditures and Results), can help you search for the latest details on NIH-funded research, publications, and patents.
RePORTER also lets you verify that your grant information is correct, and if necessary, submit a request to correct an error.
These are just a few useful tools RePORT offers. Check the RePORT site and FAQs to find out more.
The federal budget will face strong headwinds next fiscal year from both the drive to curb the deficit and the possibility of mandatory budget cuts.
Normally at this point, we are starting the annual process that culminates in our next fiscal year's appropriation.
In February, President Obama submitted his FY 2013 budget request to Congress as the first step.
It requests $30.86 billion for NIH, the same level as FY 2012, and $4.495 billion for NIAID, an increase of $10 million (0.2 percent).
However, in the aftermath of the Budget Control Act of 2011, the inability of the congressional "super committee" to agree to a plan to reduce the U.S. deficit by at least $1.5 trillion casts a shadow on our FY 2013 budget.
As a result, the federal government's discretionary spending, which includes NIH, may be subject to automatic cuts up to 10 percent or more due to a mandatory process called sequestration.
For NIH, that could translate to a loss of approximately $3 billion a year starting in January 2013.
Few in Congress want such severe measures, and Congress has taken on the formidable task of addressing both sequestering and the long-term deficit.
Since it's impossible to know the outcome of Congress's efforts, we have begun designing plans to handle a loss of funds of this magnitude.
A smaller budget would pose a dilemma as we try to balance our commitments to existing grants with the need to fund new applications.
Nevertheless, it appears that if we are forced to absorb a large budget cut in FY 2013, our payline would drop to the 8 percentile.
Other measures are also likely, for example, reducing budgets for noncompeting grants and contracts as well as our intramural program by up to 10 percent, and cutting initiatives up to 20 percent.
We'd Like to Hear From You
Obviously, we recognize that such major cutbacks would have a significant impact on our research programs and investigators.
In trying times such as these, we'd very much appreciate hearing your take on priorities and other possible avenues we could pursue.
For example, should NIH get a flat or even a lower budget, would you prefer that we reduce the number of new awards or cut budgets for noncompeting grants?
Go to FY 2013 President's Budget for HHS to see all data on the President's budget request.
Now that NIH has posted the Parent Announcement for electronic administrative supplement requests, you may be wondering which method to choose. Here's a summary.
For details on how to proceed with each approach, see our Administrative Supplements to Grants and Cooperative Agreements SOP and work with your business office.
Keep in mind that the changes just give you more ways to send in your request—there is no new program or set-aside associated with this parent announcement.
Here's news from around NIH.
Give Input on Using Chimpanzees in NIH-Supported Research. With this request for information, you can have your say on how NIH should implement recommendations outlined in the Institute of Medicine's report Chimpanzees in Biomedical and Behavioral Research: Assessing the Necessity. Submit comments by April 10, 2012. Read the February 10, 2012, Guide notice for full details.
New Report Proposes Standardized Outcome Measures for NIH-Supported Asthma Clinical Trials. For asthma clinical research, NIH plans to require researchers to use a set of common measures and data collection methods. Stay tuned for details on the requirements and schedule. See the March 2, 2012, News Release.
Comment on Proposed Changes in Cost Principles, Administration, and Audit of Grants and Cooperative Agreements. Tell the White House Office of Management and Budget your thoughts on proposals to reduce burdens on institutions by streamlining compliance rules. For details on changes and instructions on how to respond, read the February 28, 2012, Federal Register notice. Deadline for comments is March 29.
Funding opportunity announcements (FOAs) are so packed with information that you may need help making heads or tails of it. When you need clarification or answers about a FOA's research-related aspects, get in touch with the NIAID staff member listed in the FOA under Scientific/Research Contacts in Section VII. Agency Contacts.
We advise you to touch base with the NIAID scientific contact even if you don't need preapproval.
You must contact that person to get preapproval before you apply for some types of grant applications, e.g., big grants and conference grants.
But we advise you to touch base with the NIAID scientific contact even if you don't need preapproval.
For example, if you plan an NIAID Resource Related Research Projects for AIDS, Allergy, Immunology, and Transplantation or phased innovation (R21/R33) application, you benefit from contacting the NIAID staff person listed in the FOA to begin discussing your proposed submission, clarify the scope of the FOA, and get answers to any questions you may have.
With tight budgets and stiff competition for funding, it's particularly important to ensure that your proposed research aligns with the Institute’s scientific priorities. Keep in mind that funding depends on several factors, including relevant program priority areas of interest, scientific and technical merit, and availability of funds.
Before you move ahead with preparing your application, you may want to email your FOA's scientific contact a one-page description of your project to solicit feedback on the viability of receiving an award and get confirmation that you're on the right track. In the long run, this step could save you time and effort.
Feel free to send us a question at firstname.lastname@example.org. After responding to you, we may include your question in the newsletter, incorporate it into the NIAID Research Funding site, or both.
"Do you have any R03 or R21 samples that can be shared?"—anonymous reader
We are now working with R21 PIs to post their applications, but it will take some time to complete the review and redaction process. We expect to have samples within a few weeks at the earliest.
We don't plan to post R03s because the budget limit of $50,000 makes their value limited. As our Small and Exploratory/Developmental Research Grants SOP states, R03s are for experienced investigators seeking short-term funding.
You can read more about the grant types and get our take on them in Choose the Grant in the Strategy for NIH Funding.
See these and older announcements at NIAID Funding Opportunities List.
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Last Updated March 29, 2012
Last Reviewed March 14, 2012