See the Glossary for more terms.
NIH published this funding opportunity announcement (FOA) in a January 24, 2014, Guide notice.
The questions and answers below are for the U01 opportunity. For those applying for the R01 or R21 companion FOA, see the following:
Yes. The NIH intramural investigator needs an eRA Commons account even though the South African investigator is responsible for submitting the application.
The intramural investigator must enter his or her eRA Commons ID in the “Credential, e.g., agency login” field of the Senior/Key Person Profile section.
To obtain an eRA Commons account, NIH intramural investigators should contact the following staff members:
Include a statement that you are an intramural scientist with NIAID and that all support comes from NIH. Junior colleagues can do the same, and they don't need to list their salaries.
You'll need to get a letter from your scientific director or designee that confirms you'll be able to collaborate on the project. You will include the letter in your application as a Letter of Support.
You do not need to get certification of IRB approval before you submit your application. It is one of the items NIH requests "just-in-time," i.e., after an application has been peer reviewed and is within a range of possible funding. Therefore, you may note IRB approval as "pending."
For more information on just-in-time, read the Just-in-Time SOP and Just-in-Time questions and answers.
Go to the Biographical Sketch Format Page.
There is no form for facilities. Simply label your pdf file as Facilities and Other Resources. As the U.S. PI, designate your site for the work as the U.S. part. Keep in mind that since investigators from both countries submit a single application, this attachment should include both the U.S. and South African information and be clearly labeled.
Yes. If your application consists of only two PIs (one from South Africa and one from the U.S.), the Leadership Plan and Collaboration Plan would basically be the same.
That said, the Collaboration Plan is normally not limited to the PIs; rather, it should include everyone, e.g., all collaborators and other key personnel, involved in the project, and describe the coordination of multiple sites in which the work is being conducted. Note that there may be some redundancy between the Collaboration Plan and Leadership Plan.
If your two plans are essentially the same, state that this is the case in your Collaboration Plan, which goes in Other Attachments of the Research & Related Other Project Information section of your application.
Go to MRC-NIH Grant Writing Workshop Presentations.
Yes. See Grants.gov Registration Instructions for Domestic and Foreign Institutions.
The deadline is 5 p.m. local time on April 22, 2014, but you may submit your application to Grants.gov starting March 22. We advise that you give yourself plenty of time to submit so you can resolve validation issues that may arise. To learn more, go to Passing Validations in the Strategy for NIH Funding.
Key personnel are contributors who provide intellectual input to the research program. See our glossary term key personnel.
Yes. You should apply with a budget that fits the scope of research that you intend to complete.
South African institutions are entitled to 8 percent F&A costs of modified total direct costs (all requested costs except for equipment and alterations and renovations, including 8 percent F&A on the U.S. site costs).
U.S. institutions are entitled to their full negotiated F&A rates.
For more information, see Facilities and Administrative Costs in the Grants Policy and Management Training for Foreign Investigators.
See What Are Allowable Costs? in the Grants Policy and Management Training for Foreign Investigators.
When grantees draw funds from PMS, the system converts the amount from U.S. dollars using the most current exchange rate.
At least 50 percent of the total costs of the collaborative research must be conducted in South Africa.
Yes. However, there must be a minimum of one from the United States and one from South Africa.
Reviewers for these applications will be South African and U.S. scientists who 1) demonstrate appropriate scientific expertise and breadth of perspective and 2) do not have any conflicts of interest.
Reviewers consider the following core review criteria, as well as other criteria that may apply specifically to the FOA.
For more information, see Section V. Application Review Information of the FOA.
No.The program is open to both new and previously established collaborations.
A letter of intent is not required or binding, but if you choose to submit one, include at least the title of the research project, names of PIs, and institutions.
Eligible South African organizations and institutions are legal entities that perform research and development as part of their functions.
These include units performing research with the provincial and national government departments, as well as other research-performing public and private institutions and entities supporting those departments in fulfilling their mandates.
The organization or institution is not required to be listed as a “declared research institution” in Schedule 1 of Government Gazette No. 37123. That list was established for funding directly from the South African National Research Foundation, not for funding in general, so it is not relevant to this opportunity.
For help determining whether your organization or institution is eligible to apply, contact Arlene Smith (firstname.lastname@example.org) at the South African Medical Research Council (MRC).
I understand that for a multiple PI application, there must be a contact PI. Can he or she be from either the U.S. or South African institution?
No. The contact PI must be an eligible investigator from the South African institution, and therefore the South African institution must submit the application. For more on multi-PI applications, see What are some key points to know about multiple PI applications (which this FOA requires)?, below.
No. Only one letter of intent is needed for each application, and the South African contact PI is the one who should submit it.
The following clinical research guidance outlines what would be responsive:
As for what would be considered nonresponsive: clinical trials involving experimental interventions (drugs, devices, biologics, behavioral) and unapproved uses of approved agents.
For a multiple PI application, you should know that:
For more information, read Multiple PI Facts in the Strategy for NIH Funding, but note that the Facts refer to investigator-initiated applications so some of the information does not apply in this case.
Though you can't be a PI, you can still be part of the proposed project as key personnel.
Yes. NIH encourages new investigators, especially early-stage investigators (ESIs), to apply.
To find out whether you qualify as new or ESI, go to How to Qualify for New and Early-Stage Investigator Status in our New Investigator Guide to NIH Funding.
Yes. Since you had children after completing your terminal degree, you would likely get an ESI extension of one year (six months for each child). For information on requesting permission for an extension, go to How do I request an extension of my ESI status? on NIH's Frequently Asked Questions About the NIH ESI Policy page.
Yes. See the International Awards section of our Questions and Answers as well as other resources on our International Awards portal.
Yes. Applications must include at least one PD/PI who is an NIH intramural investigator (i.e., someone conducting research within an NIH lab or clinic) and one PD/PI who is affiliated with an eligible South African institution. (See the next questions.) If they do not, applications will be considered nonresponsive and will not be reviewed.
For research partnerships involving South African researchers and U.S. extramural investigators, see the related R01 and R21 Guide notices.
NIH intramural PD/PIs who present at site visits are allowed to apply for funding under the program if they provide a letter of support from their scientific director. Other permanent scientific staff (e.g., staff scientists and clinicians) are also eligible to apply if they provide a letter of support from their scientific director and (if applicable) from their branch chief.
No. As long as the PD/PI is a full-time employee of an eligible South African institution or under a long-term contract for the duration of the award, he or she is eligible. Keep in mind that it's important to document this in the application.
No. Investigators from both countries will work together to prepare one application, which the South African institution must submit and which should follow the multiple PI approach. See next question.
NIH plans to commit approximately $0.6 million to fund up to four awards in FY 2015.
Yes. Budgets are limited to a total cost of $225,000 each year with a limit of $175,000 each year for the South African institution.
NIH intramural investigators are limited to $50,000 in costs each year. They may not include salary or overhead in the proposed budget.
To see what research areas related to HIV/AIDS and TB are of interest, read the examples in the Research Objectives section of the FOA. Keep in mind that these are broad topics under which your proposed project may fall.
If you'd like to know whether your research is appropriate (i.e., responsive) for this FOA, contact the Scientific/Research Contact(s) listed in the announcement. Consider submitting an optional letter of intent (LOI), which is due a month before the application. Learn more about LOIs in our December 19, 2013, Funding Newsletter article "Why Writing Letters of Intent Helps Us Help You."
Clinical trials (stage I, II, III, or IV) are not allowed through this FOA. Applications proposing trials will be deemed nonresponsive and will not be reviewed.
No. As with applications that propose clinical trials, those that include the use of select agents will be nonresponsive to this FOA and will not be reviewed.
For a list of what is considered a select agent, go to HHS and USDA Select Agents and Toxins, and to see if an agent is exempt or excluded, see Select Agent and Toxin Exclusions. Find other resources at NIH's Select Agent Information.
Contact the Scientific/Research Contact(s) listed in the FOA.
Last Updated April 09, 2014
Last Reviewed April 09, 2014