See the Glossary for more terms.
Table of Contents
You may, though you must get NIAID approval before applying. In deciding whether to fund a big grant, NIAID weighs the effect on its budget as well as the priority of the research. For details, see the Big Grants SOP.
NIH policy for applications with budgets of $500,000 or more in direct costs in any year requires that you submit documentation with your application stating you have discussed it with an NIAID program officer, and NIAID has agreed to accept it.
You must seek approval from the program officer at least six weeks before applying. Your program officer will send you an acceptance letter to include with your application. See the Big Grants SOP.
Clinical trial applications follow their own process—go to Investigator-Initiated Clinical Trial Resources for more information.
No. You must include an acceptance letter from your program officer with your cover letter. For details, see the Big Grants SOP.
If your big grant application is in response to an RFA, contact the program officer listed in the funding opportunity announcement. You can find this person listed under Scientific/Research Contacts.
If your big grant application is investigator-initiated, e.g., a large R01 or a P01, you will need to find a program officer to consult with based on your area of science. Choose the most appropriate extramural research division:
For more information, see the Big Grants SOP.
Yes, you need to respond to a specific FOA. For more information on submitting a big grant application, see our Big Grants SOP.
No. The $500,000 limit excludes any subaward F&A costs.
Work with your program officer—submitting a big grant application is best approached as a team effort.
It's much better to call or write while still planning your application, so your program officer can advise you on the feasibility of getting an award. That way, you don't waste time writing an application we may reject. To find a program officer, visit When to Contact an NIAID Program Officer. Read the Big Grants SOP for more information.
Without program staff approval, you face the following consequences:
Yes, you need permission any time your request could exceed $500,000 in any year. For example, if you ask for $499,000 in direct costs in the first year, the out years could be more than $500,000, even if you don't request an annual increase.
Only if you are the PD. Project and core leaders do not contact NIAID staff.
No, because large requests strain our budget and compromise grant numbers. When deciding what to fund, we weigh the effect on our budget as well as the priority of your proposed research.
No. Getting an annual budget increase depends on our annual financial management plan, which we post on Paylines and Funding. You should start checking this site at the beginning of a new fiscal year, keeping in mind that our numbers usually change later in the year when our budget is final.
No. A detailed budget is a requirement for any grant requesting more than $250,000 in a year. See Plan Your Budget in the Strategy for NIH Funding.
We usually convert large clinical research grants and epidemiology studies into cooperative agreements when NIAID staff need to participate substantially in the research.
Like all clinical awards, cooperative agreements are subject to NIAID Clinical Terms of Award and to additional requirements for NIAID staff participation. Also see Conversion of Grants to Cooperative Agreements SOP.
No. All institutes follow the same NIH policy.
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Last Updated June 13, 2013
Last Reviewed June 10, 2013