NIAID encourages applications in the areas of HIV/AIDS prevention and treatment. The mission of Division of AIDS (DAIDS) is to help ensure an end to the HIV/AIDS epidemic by increasing basic knowledge of the pathogenesis and transmission of the human immunodeficiency virus (HIV); supporting the development of therapies for HIV infection and its complications and co-infections; and supporting the development of vaccines and other prevention strategies.
Below are areas of interests from DAIDS. The subject matter expert is available to answer questions and advise on the application process.
If you do not see your HIV/AIDS-related topic here, the application may not be prioritized but will still be reviewed. Contact Daniella Livnat or Brigitte Sanders if you have any questions about your application and don’t see an appropriate subject matter expert below.
Preclinical development and evaluation of HIV vaccines, adjuvants, and delivery systems in animal models using SIV, SHIV, or HIV.
Vaccines that enhance innate and mucosal immunities and induce broadly reactive and long lasting neutralizing antibodies are program priorities.
Jim BradacPreclinical Research and Development Branch
Translational research to facilitate advancing novel promising basic SIV/HIV vaccine research concepts into HIV vaccine products, including: 1) vector optimization for expression, safety, and manufacturability; 2) upstream and downstream development activities; 3) analytics development to support in process testing and release; 4) formulation development; 5) novel adjuvant approaches; 6) GMP manufacturing; and 7) preclinical safety and toxicology modeling.
Jeffrey K. PullenVaccine Translational Research Branch
Development of rapid diagnostic tests to distinguish HIV-vaccinated and HIV-infected individuals. HIV Env immunogens formulated with immunological adjuvant(s): Development of assays to ensure proper formulation, antigen/adjuvant integrity and potency, and characterization of immunological space post-vaccination. Evaluation and monitoring of vaccine safety and efficacy by identifying biomarkers of safety, autoimmunity, inflammation and immunogenicity.
Jim LaneVaccine Clinical Research Branch
Preclinical development of single and combination non-vaccine biomedical prevention candidates (topical microbicides, PrEP and multipurpose prevention technologies (MPT)) which prevent the transmission of HIV in the genital and gastrointestinal tracts of men and women.
Development of oral, injectable, implantable, and topical sustained delivery strategies for topical microbicides, PrEP, and MPT.
Jim A. TurpinPreclinical Microbicide and Prevention Research Branch
Discovery and development of agents or strategies for pre-exposure prophylaxis (PrEP) (single or multiple agents, immunological, pharmacological, or other potential approaches directed against viral and/or host targets). Development of pharmacological tools to examine PK/PD in fluids and tissue, new formulation and delivery systems (including nanotechnology-based approaches) for coitally dissociated use, and optimization of animal models for screening of candidate agents.
David BurnsClinical Prevention Research Branch
Development of novel assay for the determination of HIV incidence.
These diagnostic assays should identify HIV incidence in the first year of infection, be based on B and non-B subtypes, differentiate those with early vs. chronic HIV infection and latent infection; and include the development, incorporation, and validation of process controls.
Usha SharmaClinical Prevention Research
Development of formulation strategies to deliver antiretrovirals to specific target cells or tissues.
Daniella LivnatDrug Development and Clinical Sciences Branch
Preclinical discovery and development of antimicrobial agents directed against Mycobacterium avium, Mycobacterium abscessus, Pneumocystis Pneumonia, and Cryptococcus neoformans (and other pathogenic fungi).
Development and delivery of nanotechnology-based therapeutics to target pathogen or pathogen-infected cells.
Chris LambrosComplications and Coinfections Research Branch
Small molecule inhibitors of viral and cellular targets not yet covered by FDA-approved antiretrovirals; HIV therapeutics discovery including high-throughput screening; development of nanotechnology-based therapeutics; HIV gene therapies, including vector design; animal models for HIV therapeutics and cure strategies.
Brigitte SandersTargeted Interventions Branch
HIV therapeutic vaccines, monoclonal antibody discovery and development for therapeutic use; immune-based HIV cure strategies; assays to measure the latent HIV reservoir
Tony ConleyTargeted Interventions Branch
Development of novel methods for the diagnosis of active and latent TB infection in HIV-positive or HIV-negative infants and children.
Lakshmi JayashankarContractor, Henry M. Jackson Foundation
Development and evaluation of practical and affordable tests to measure viral load, drug toxicities, and drug resistance to monitor populations in resource-poor settings.
Joseph FitzgibbonDrug Development and Clinical Sciences Branch
Development of rapid tests for the detection of ARTs in various human matrices (e.g. blood, urine, hair).
Hao ZhangDrug Development and Clinical Sciences Branch
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Last Updated February 10, 2016
Last Reviewed May 01, 2014