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Small Business Program

The NIAID Small Business Innovation Research (SBIR)/Small Business Technology Transfer (STTR) program awards more than $120 million annually to help domestic small businesses engage in research and development with the potential for commercialization and public benefit.

We welcome entrepreneurs and small business leaders to this website to explore grant and contract funding opportunities and engage in collaboration with NIAID.

The SBIR and STTR Programs are one of the largest sources of early-stage technology financing in the United States. SBIR and STTR are government set-aside programs for domestic small businesses. Both programs seek to increase small business participation and private-sector commercialization of technology developed through federal research and development. The SBIR Program funds early-stage research and development at small businesses. The STTR Program has the unique feature of requiring the applicant organization to formally collaborate with a research institution in Phases I and II.

To learn more about the NIAID SBIR and STTR program, go to Program Structure.

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Announcements and Upcoming Events

NEW: Leidos Health’s Life Sciences is partnering with NIH to match high-scoring, unfunded NIH proposals with private biomedical foundations and industries seeking to fund promising research through the Online Partnership to Accelerate Research (OnPAR). To learn more about OnPAR, see our April 6, 2016 Funding News article "Give Your Application a Second Chance With OnPAR."

NEW: Notice of a Change to the Purpose in RFA-AI-16-009, "NIAID SBIR-Technology Transfer Direct Phase II (R44)"

NEW: Notice of NIAID's Interest to Highlight High-Priority Zika virus (ZIKV) Research Areas

NEW: Department of Defense Awards—FY17 Military Infectious Diseases Applied Research Award and FY17 Military Infectious Diseases Clinical Study Award. Will fund research addressing combat-related or trauma-induced wound infections. Preference given to proposals involving carbapenem- and multidrug-resistant organisms. Preapplication deadline is January 25, 2016. See full program announcement and application instructions at Congressionally Directed Medical Research Programs Department of Defense Funding Opportunities.

NEW: SBIR/STTR Commercialization Readiness Pilot (CRP) Program: Technical Assistance and Late Stage Development (SB1)

ASSIST Now an Option for Small Business Grant Applications

DEADLINE REMINDER: The next HHS/NIH SBIR/STTR application deadline is September 5, 2016.

HHS Changes Standard Due Dates for SBIR/STTR Grant Applications - See more at: 

Four NIAID-funded companies (Bioo Scientific, Celdara Medical, LI-COR Biosciences, and Techshot, Inc.) received SBA Tibbetts Awards for Innovative and Outstanding Contributions


Last Updated April 18, 2016

Last Reviewed July 27, 2015