See the Glossary for more terms.
Some links will work for NIAID staff only.
This standard operating procedure (SOP) includes the following sections: Purpose, Procedure, Contacts, and Links.
To support investigator-initiated research projects or training grants with total direct costs of $500,000 or more in any year of the grant.
Investigators must ask NIAID to agree to accept assignment of any investigator-initiated application that requests $500,000 or more in direct costs for any year (excluding subaward facilities and administrative costs).
NIAID accepts assignment of a limited number of large grant applications and weighs their prospects carefully. The Center for Scientific Review (CSR) will return applications that lack NIAID's approval to accept assignment.
Although investigators can ask for up to $499,000 without our approval, they should contact NIAID if they come anywhere close to that level for the following reasons:
NIH's big grant policy also applies to multiproject applications even if none of the individual projects request $500,000 or more. It does not apply to applications submitted in response to requests for applications.
Clinical trial applications follow their own process—go to Investigator-Initiated Clinical Trial Resources for more information.
Applicants with questions should read Communicating With NIAID—How to Get Help.
Office of Research Training and Special Programs—Contact for NIAID Staff
NIAID Receipt and Referral—Contact for NIAID Staff
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Big Grant Applications Questions and Answers
NIAID Funding Policy and Process SOP
Last Updated March 22, 2016
Last Reviewed March 20, 2015