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Animals in Research for Grants

Lock icon: This link will not work for public visitors.Some links will work for NIAID staff only.

This standard operating procedure (SOP) includes the following sections: Purpose, Procedure, Contacts, and Links.

Purpose

To require institutions applying for animal research awards to comply with NIH policies for the care of research animals.

Procedure

To receive PHS awards, applicants working with research animals must abide by the PHS Policy on Humane Care and Use of Laboratory Animals and follow the American Veterinary Medical Association Guidelines for the Euthanasia of Animals

They must also base their programs of animal care and use on the Guide for the Care and Use of Laboratory Animals.  To clarify how to use this guide, NIH’s Office of Laboratory Animal Welfare (OLAW) issued Position Statements, including an Adoption and Implementation Plan.

PHS policy is summarized in the brochure What Investigators Need to Know About the Use of Animals.

PHS's definition of research animal use includes production of custom antibodies and animals obtained for their tissues. Read more at Applicability of the PHS Policy.

Applicants must follow instructions in the funding opportunity announcement. Contract offerors must follow instructions in the solicitation.

An application involving research animals must address the five points listed in the Vertebrate Animals Section of the Research Plan. If it does not, Center for Scientific Review or NIAID (depending on where it is reviewed) will designate it incomplete and code it accordingly. See Answer the Five Points in the Vertebrate Animals Section for more information.

For grants, certain animal research codes in IMPAC and on an application's summary statement indicate a bar to award that must be resolved before funding. For a list of codes, go to Research Animals Involvement Codes.

Find more information on animal research requirements at Animals in Research.

Investigators

Program Officers

  • For competing applications:
  • For noncompeting applications:
    • Review annual progress reports.
    • Use the Program Officer Checklist in the IMPAC Program Module to indicate concerns or changes in animal care and use.
  • If a grant is transferring to a new grantee:
    • Review and approve the new grantee's response to the five points in the Vertebrate Animals Section of the Research Plan.
    • Check that the new grantee has an assurance on file with OLAW and a certification of IACUC approval.

Grants Management Specialists

  • Ensure that animal welfare assurances and IACUC certifications are in place before issuing competing and noncompeting awards. If documentation is not in place, contact OLAW and request that it negotiate the documentation with the applicant.
  • If animal welfare assurances or IACUC approvals are still pending at the end of the fiscal year, contact the OLAW Lock icon: This link will not work for public visitors.Contact for NIAID Staff to change the code and allow a restricted award.
  • If a grant is transferring to a new grantee, confirm that the new grantee has submitted the five points in the Vertebrate Animals Section of the Research Plan. Also ensure that its animal welfare assurance and IACUC certification are in place.

Scientific Review Officers

  • Ensure that peer reviewers for applications evaluate a project's compliance with federal requirements for animal research, coding applications based on responses to the five points in the Vertebrate Animals Section of the Research Plan. See Answer the Five Points in the Vertebrate Animals Section for more information.

Contacts

Applicants and grantees should go to Communicating With NIAID—How to Get Help to determine who to contact.

Offerors should ask the primary contact listed in the RFP. See the Extramural R&D Solicitations list, or, see the Office of Acquisitions staff listing.

Lock icon: This link will not work for public visitors.Contact for NIAID Staff

Lock icon: This link will not work for public visitors.Contact for NIAID Staff

Lock icon: This link will not work for public visitors.Contact for NIAID Staff

If you have knowledge to share or want more information on this topic, email deaweb@niaid.nih.gov with the title of this page or its URL and your question or comment. Thanks for helping us clarify and expand our knowledge base.

Links

Vertebrate Animals in Research questions and answers

OLAW: Office of Laboratory Animal Welfare

Animal Welfare Assurance for Foreign Institutions

Grant Application, Electronic SOP

Grant Application, Paper SOP

IMPAC SOP

Worksheet for Review of the Vertebrate Animal Section (PDF)

Last Updated August 18, 2014

Last Reviewed August 18, 2014