See the Glossary for more terms.
Related Extramural SOPs: Career Development Grants SOP, Research Training SOP, and Research Training Grants SOP
Go to NIH's Rigor and Reproducibility page to learn how to address rigor and reproducibility in grant applications due on or after January 25, 2016. Pay close attention to the Timeline.
NIH awards National Research Service Award (NRSA) institutional research training grants to institutions of higher education to defray the costs of training graduate students or postdoctoral scientists.
Applicants must apply electronically.
NRSA Institutional Research Training Grants (T32)
Grant is up to five-year duration, with the chance to renew.
Domestic, non-profit, private, or public educational institution with an outstanding research and academic environment, including suitable staff and facilities.
Senior investigators who head research or training programs generally apply for T32s on behalf of their institution.
Requires different elements than R01s. Institution must show:
In preparing applications, institutions should use the SF 424 Data Tables.
NRSA Short-Term Institutional Research Training Grants (T35)
Pre-doctoral trainees only. Grant is up to five years, with the chance to renew.
Domestic, non-profit, private, or public institutions with a high quality research program in the proposed areas, including suitable staff and facilities.
Allow eligible institutions to develop or enhance research training opportunities for people interested in careers in biomedical and behavioral research.
Institution must show:
Career development awards help scientists with diverse backgrounds to enhance their careers in biomedical research. Applicants must apply electronically.
Except for the K99/R00 award, applicants must be U.S. citizens or have permanent residency status (an Alien Registration Receipt Card, Form I-551). Non-citizens who have applied for a Form I-551 and expect to receive it by the earliest award date may apply, though those with student or other temporary visas are not eligible.
Investigators may request part-time appointments, a reduction in percent effort, and other adjustments. For more information, see the Career Development Grants SOP.
Duration of three to five years, not renewable.
Salary up to $75,000 (if institutional base salary is equivalent or more) plus fringe benefits.
Research support of $25,000 each year.
Facilities and administrative costs based on eight percent of modified total direct costs.
Minimum nine person months effort required each year.
In the last two years of a K01 award, NIH permits concurrent salary support from a peer-reviewed grant from any federal agency if 1) your K award is active, and 2) you are a PI on a competing research project grant or director of a subproject on a multicomponent grant from NIH or another federal agency.
Research or health-professional doctoral degree holders with research plans in epidemiology, modeling techniques, and outcomes research only.
Applicants who are more junior in terms of their research career.
Institution must have a well-established research and clinical career development program and qualified faculty in clinical or basic research to serve as mentors.
Mentor is recognized as an accomplished investigator in the proposed research area and has a track record of success in training independent investigators.
Proposes a period of study and career development consistent with previous research experience.
Mentored Clinical Scientist Development Award (Parent K08)
Mentored Patient-Oriented Research Career Development Award (Parent K23)
Duration of three to five years, not renewable. For K08, award length depends on experience.
For all K08 and K23 awards:
In the last two years of a K08 and K23 award, NIH permits concurrent salary support from a peer-reviewed grant from any federal agency if 1) your K award is active, and 2) you are a PI on a competing research project grant or director of a subproject on a multicomponent grant from NIH or another federal agency.
Commitment to a career in biomedical or behavioral research.
For K08, clinical doctoral degree such as M.D., D.V.M., or O.D., a professional license to practice in the United States, and current work in biomedical or behavioral research, including translational research.
For K23, you're eligible if you have a clinical doctorate, completed specialty or subspecialty training, and perform research that requires direct work with patients.
Three main elements to success:
NIAID will not accept K-series applications proposing to conduct new, independent clinical trials.
NIAID Career Transition Award (K22)
Duration of two years, not renewable.
Direct costs of $150,000 in the first year and $100,000 in the second year. Up to $50,000 of the award can be spent on the PI's salary each year (exclusive of fringe benefits); the remainder is at the PI’s discretion to utilize the award per the research described in the application. (Salary for mentors, secretarial and administrative assistants, etc. is not allowed). If funds are not needed for the PI’s salary support, they may be used for research expenses.
Postdoc with no more than five years of research experience.
In the first of two application phases, applicant submits a CV that details career goals, a Research Plan, and three letters of recommendations.
Within a year of receiving a fundable score, investigator must be offered an assistant professorship at an academic institution. To qualify for the second phase, he or she must show that the position offers an assistant professorship, laboratory, significant start-up funds, and minimal teaching or other responsibilities.
Unaffiliated applicants should read Special Instructions for Submitting K22 Applications From Unaffiliated Applicants Using the SF 424 (R&R).
Midcareer Investigator Award in Patient-Oriented Research (Parent K24)
Duration of three to five years (minimum of three), renewable.
Salary is based on full-time institutional salary up to the current NIH salary cap multiplied by the percentage of effort plus fringe benefits.
Research development costs of up to $50,000 each year.
Minimum effort of three to six person months required each year.
Mid-career clinician scientists and Ph.D. earners with Ph.D. degrees in a clinical field who are committed to patient-oriented research and has concurrent research support, such as R01, pharmaceutical company funding, or participation in a clinical trial.
Should have completed clinical training within the past 15 years, although NIAID allows some flexibility on this requirement.
Interest in mentoring or teaching other young physicians in clinical research.
Incorporates 75 percent science and 25 percent mentoring, teaching, and career development, not straight science like an R01.
Includes strong justification for additional funding and plans for mentoring or sponsoring junior researchers.
Mentored Quantitative Research Development Award (Parent K25)
Duration of three to five years (minimum of three), not renewable.
Research development costs of $20,000 each year.
In the last two years of a K25 award, NIH permits concurrent salary support from a peer-reviewed grant from any federal agency if 1) your K award is active, and 2) you are a PI on a competing research project grant or director of a subproject on a multicomponent grant from NIH or another federal agency.
Junior faculty member with an advanced degree in engineering or quantitative science, such as Ph.D. or M.S.E.E., who wants to integrate this expertise with biomedicine.
Former PIs on NIH research projects or subprojects and previous recipients of certain awards aren't eligible.
Less detailed Research Plan suffices because peer reviewers recognize investigator's limited experience.
NIAID encourages applications requesting up to two years for the K99 and two years of support for the independent R00 phase of the award, not renewable.
Salary up to $75,000 (if institutional base salary is equivalent or more) plus fringe benefits.
Research development costs up to $25,000 each year.
For K99 phase, facilities and administrative costs based on eight percent of modified total direct costs.
Clinical or research doctoral degree with no more than four years of postdoctoral research training at the time of submission, who has plans to apply for an assistant professorship at an academic institution.
Note: For applications due on or after February 12, 2016, the applicant should have no more than four years of postdoctoral research experience as of the relevant application due date regardless of whether the application is new or a resubmission. Parental leave or other well-justified leave of generally less than 12 months duration is not included in the 4-year eligibility limit.
For further details, including how this affects resubmissions, see our Pathway to Independence Awards (K99/R00) SOP.
Should include a Career Development Plan, Research Plan with a description of the project to be pursued in the R00 phase, and at least three letters of reference. During the initial mentored (K99) phase, the investigator must secure a tenure-track, full-time assistant professor position at an academic institution.
To qualify for the independent investigator (R00) phase, the investigator's division or department chair will need to submit a letter demonstrating the institution's commitment to the investigator by providing protected research time, space, facilities, and other support needed to conduct the proposed research.
Last Updated January 15, 2016
Last Reviewed January 15, 2016