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Medical Countermeasures Against Chemical Threats

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Nervous System

Short-Term Goals

  • Initiate appropriate clinical studies to determine the safety and efficacy of promising anticonvulsants, such as midazolam, that would lead to Food and Drug Administration┬álicensure, and explore the use of such products in different populations
  • Establish a drug development program that includes preclinical drug screening and clinical studies on potential anticonvulsant and neuroprotective therapies
  • Identify and validate appropriate models for preclinical drug testing, including in vitro systems and animal models, to investigate the effects of high and low levels of exposure to nerve agents
  • Expand knowledge of how different nerve agents are absorbed, distributed, metabolized, and eliminated by the body, and explore the interactions of agents with current antidotes
  • Determine optimal drug formulations of the most promising medical countermeasures, and safe and effective route(s) of administration
  • Explore the practical use of enzyme bioscavengers that could be used to treat victims after exposure to nerve agents
  • Establish a collaborative research effort with the U.S. Department of Defense (DoD) to develop medical countermeasures against nerve agents of greatest concern, capitalizing on current and future DoD research
  • Develop a comprehensive medical research program that involves academia and industry in the development of specific medical countermeasures directed against nerve agents

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Last Updated February 29, 2008