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Humanized Rodent Model Workshop

September 26, 2007
Rockville, MD

It has long been recognized that a small animal model with a reconstituted human immune system would be extremely useful in the study of HIV/AIDS pathogenesis and for the evaluation of vaccine and therapeutic strategies to combat this disease. By early 2007, a number of reports on rodent models with a humanized immune system capable of being infected by and responding to HIV were published.

The New Humanized Rodent Model Workshop, organized by the NIAID Division of AIDS was held for the purpose of bringing together key model developers and potential users. The meeting included a discussion about the current status of the models, future plans, as well as potential use of the models for addressing critical issues in basic immune response studies, pathogenesis, therapeutics, vaccines and microbicides development.

The workshop summary is at http://www.aidsrestherapy.com/content/5/1/3

Issues Addressed by the Speakers

  1. Model Advantages
  2. Possible Studies
  3. Limitations
  4. Cohort Size
  5. Model Availability
  6. Stem Cells and Fetal Tissue
  7. Model Development
  8. Human Cell Distribution
  9. Current Scientific Studies
  10. HLA Restriction and Antibody Responses

Questions Addressed by Panel Discussion

  1. What are the hindrances to widespread use of the models for pathogenesis studies?
  2. What is needed to determine the feasibility of the models for vaccine and therapeutic testing, including testing of microbicides?
  3. What can be done to overcome some of the current blocks for the models to support quality assays? Some of these include CD34 cell suppliers, mice, how cells are treated, virus, others.
  4. What can the NIAID/NIH do to facilitate solutions to the above questions?

Last Updated July 21, 2010

Last Reviewed July 21, 2010