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HIV Topical Microbicides Research


The main goal of the NIAID HIV Topical Microbicide Research Program is to support research that leads to identification and development of safe, effective, and acceptable topical microbicides. NIAID’s topical microbicide research is outlined in the NIAID Topical Microbicide Strategic Plan, and includes basic research through preclinical development and clinical trials. More specifically, NIAID microbicide research objectives aim to support

  • Fundamental research to delineate the early steps in HIV infection and transmission at mucosal surfaces in cervicovaginal and rectal tissues
  • Discovery and development of safe and effective formulations and delivery methods
  • Development and utilization of suitable animal models for safety and efficacy testing
  • Research into the acceptance and use of microbicides by conducting prevention and behavioral studies
  • Exploratory Phase I clinical trials to assess the relevance of and validate new approaches for determining the safety and efficacy of candidate microbicides
  • Iterative preclinical to clinical translational research to evaluate and optimize topical microbicide formulations and strategies
  • Clinical trials to determine safety, efficacy/effectiveness, and acceptability of candidate topical microbicides

Additional Information

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Last Updated June 18, 2010

Last Reviewed March 26, 2010