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Laboratory of Allergic Diseases

The Laboratory of Allergic Diseases (LAD) conducts an integrated program of basic, translational, and clinical research focused on immunologic diseases, with an emphasis on understanding the pathophysiology, diagnosis, and treatment of allergic disorders. This work is accomplished by a team of principal investigators, staff scientists, staff clinicians, biologists, nurses, and fellows working within organizational groups based on specific research interests. LAD includes units and sections focused on mast cell, eosinophil, and T-cell biology; G-protein coupled signal transduction; and immunodeficiency.

LAD investigators are conducting clinical studies designed to do the following:

  • Identify the basis of immunodeficiency disorders with a focus on the impact on allergic inflammation
  • Understand the basis of mast cell proliferative disorders and identify novel approaches to therapy
  • Explore the role of intrinsic mast cell abnormalities in anaphylaxis
  • Identify the basis of systemic capillary leak syndrome
  • Understand the contribution of T cells to eosinophilic gastrointestinal disorders and food allergy
  • Study cold-, heat-, and pressure-induced allergic reactions to examine the cellular events in human allergic inflammatory reactions.

Read more about the Laboratory of Allergic Diseases.

In addition, LAD administers the National Institutes of Health Clinical Center ACGME-accredited Allergy and Immunology Clinical Fellowship Program. (ACGME is the Accreditation Council for Graduate Medical Education.) This program provides specialty training for board-certified pediatricians and internists in the care of children and adults with complex allergic and immunologic diseases, including food allergy, asthma, eczema, nasal and ocular allergy, drug allergy, hives, anaphylaxis, and immunodeficiency diseases.

Read more about the Allergy and Immunology Training Program.

Last Updated July 18, 2011

Last Reviewed July 18, 2011