Asthma and allergic diseases such as hay fever (allergic rhinitis), food allergy, and eczema (atopic dermatitis) are common conditions for all ages in the United States.
In 1971, NIAID established the Asthma and Allergic Diseases Centers, the first targeted program to promote research in the fields of asthma and allergic diseases. Initially, seven centers were funded. Today there are 11, known collectively as the Asthma and Allergic Diseases Cooperative Research Centers (AADCRCs).
The AADCRC program remains the cornerstone of NIAID efforts to promote multidisciplinary basic and clinical research on the immunological basis, pathobiology, diagnosis, treatment, and prevention of asthma and allergic diseases.
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AADCRC research aims to
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AADCRC investigators conduct clinical research studies on asthma and allergic diseases, as well as respiratory infections, to explore
The AADCRC program is conducting the following clinical trials and observational studies (see ClinicalTrials.gov for more information on individual clinical trials; observational studies are not included in ClinicalTrials.gov):
Studies have shown that some children who are infected with respiratory syncytial virus (RSV) during infancy are at high risk of developing asthma. However, it is not possible to predict who will ultimately develop asthma and, consequently, who might most benefit from vigorous attempts at preventing early viral infection. This observational study is recruiting approximately 2,000 infants during their first 6 months of life and will document and characterize all respiratory infections during their first year. The children will be followed for 3 to 4 years and will be monitored for the development of recurrent wheeze and asthma. The study will also analyze biomarkers of lung injury and host immune responses.
Using an integrated approach that combines basic, translational, and clinical research on asthma and allergic diseases, AADCRC investigators have made the following scientific advances:
Last Updated February 26, 2013
Last Reviewed March 30, 2011