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Dengue Fever

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NIAID Role in Dengue Fever Research

Scientists supported by NIAID are trying various approaches to develop vaccines against dengue. Researchers in NIAID laboratories in Bethesda, Maryland, are using weakened and harmless versions of dengue viruses as potential vaccine candidates against dengue and related viruses. Other NIAID-funded investigators are trying to develop dengue virus vaccines using recombinant proteins (with or without adjuvants), viral vectors, and DNA.

Several projects are currently ongoing to identify the host and viral factors that determine the virulence and transmissibility of different dengue virus strains.

Other researchers supported by NIAID are investigating ways to treat infected individuals and to prevent dengue viruses from reproducing inside mosquitoes.

Although dengue virus has emerged as a growing global threat, scientists know little about how the virus infects cells and causes disease. New research is beginning to shed light on how the virus interacts with humans; for example, how dengue virus damages cells and how the human immune system responds to dengue virus infection.

Much of the basic research on dengue fever is done in labs at NIAID. Read more on Dengue Research in NIAID Labs.

In February 2011, NIAID is co-sponsoring a scientific meeting titled “A Re-Emerging Challenge in the Americas: Opportunities for Dengue Research Collaboration.” The meeting will provide a forum for exchange of current information on basic and applied dengue research, identify research gaps and priorities, and promote and stimulate research collaborations in the Americas. For more information, see the conference Web site.

Research

Research Features

Mosquito microRNA Essential for Metabolism and Reproduction, NIAID Grantees Find

New Defense Mechanism against Dengue Identified in Mosquitoes

Modified Mosquitoes Could Save People from Dengue Fever

Infant Immunity May Show Path to Dengue Vaccine

NIAID Scientists Use Reverse Genetics to Develop Potential Dengue Vaccine 

Last Updated February 08, 2011