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The molecular events that affect disease transmission and human response to Ebola and Marburg viruses are poorly understood. Researchers in NIAID’s Division of Intramural Research and at the Institute’s Vaccine Research Center as well as NIAID-supported scientists at external institutions are studying all aspects of Ebola and Marburg viruses and how they cause disease.

Investigators are seeking better ways to diagnose and treat Ebola and Marburg fevers. For example, NIAID scientists, in collaboration with researchers at the NIAID-supported New England Regional Center of Excellence, are investigating molecules called cathepsin inhibitors. Cathepsins play an essential role in allowing the Ebola virus to enter and infect cells. Cathepsin inhibitors could be developed to keep the virus from entering cells and causing disease.

Research Features

Last Updated June 13, 2014

Last Reviewed June 13, 2014