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Illustration of a contact-dependent inhibition (CDI) in intra-strain growth competition
Model for the role of contact-dependent inhibition (CDI) in intra-strain growth competition. (1) A mixture of plant pathogens, some containing CDI systems, interact on a leaf. (2) The CdiA protein contacts a neighboring cell and its toxic tip, for example an enzyme that cleaves transfer RNA, is delivered. (3) Growth of the targeted cell is blocked unless it expresses the cognate CdiI immunity protein, which binds and inactivates the toxin. Many bacterial pathogens contain CDI systems. (Courtesy S. Aoki, UC Santa Barbara).

Last Updated December 06, 2010

Last Reviewed December 06, 2010