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Flu (Influenza)

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Resources for Researchers

Activity

Resource/URL

Contact

Funding

Currently active initiatives for fundamental and translational research for influenza; accepting investigator-initiated grant applications in all areas of influenza research NIAID funding opportunities for influenza investigators Vaccines:
Fred Cassels, NIAID
Antivirals:
Amy Krafft, NIAID
Basic research and diagnostics:
Rachelle Salomon, NIAID
Clinical trials:
Sonnie Kim, NIAID

Pre-Clinical Research

Conduct prospective international and/or domestic animal influenza surveillance for the rapid detection and characterization of influenza viruses with pandemic potential

Conduct research to enhance understanding of the molecular, ecological, and/or environmental factors that influence pathogenesis, transmission, and evolution of influenza viruses; and characterize the protective immune response.

Centers of Excellence for Influenza Research and Surveillance (CEIRS)

Diane Post, NIAID

Provide targeted screening and evaluation of potential therapeutic and prevention modalities for emerging infectious agents and bioterrorism pathogens using in vitro, small animal, and nonhuman primate models to test safety and efficacy In Vitro Assessment for Antimicrobial Activity Judy Hewitt, NIAID
Supports and accelerates development of therapeutic agents by providing preclinical drug development resources to the scientific community and industry partners Therapeutic Development Services Beth Spinelli, NIAID
The IEDB contains data related to antibody and T cell epitopes for humans, non-human primates, rodents, and other animal species. Detailed curation of existing antibody and T cell epitope information for numerous Influenza strains. Online analysis tools: Antibody and T cell epitope prediction algorithms, epitope conservancy, population coverage. Immune Epitope Database and Analysis Resource A. Deckhut Augustine, NIAID
Custom synthesis and distribution of soluble MHC-peptide tetramer reagents that can be used to stain antigen-specific T cells. Influenza- related reagents: Custom synthesis of human, non-human primate and mouse MHC class I and human and mouse class II tetramers (peptide provided by investigator). Three pre-made human class II tetramers containing flu matrix peptides (DRB10101, DRB10401, DRB10404). NIH Tetramer Facility A. Deckhut Augustine, NIAID

Clinical

NIAID contracts to conduct clinical trials for influenza research NIAID’s Vaccine Treatment and Evaluation Units (VTEUs) Suzanne Murray, NIAID
Provides regularly updated information about federally and privately supported clinical research in human volunteers. ClinicalTrials.gov  

Research Infrastructure

Conduct prospective international and/or domestic animal influenza surveillance for the rapid detection and characterization of influenza viruses with pandemic potential

Conduct research to enhance understanding of the molecular, ecological, and/or environmental factors that influence pathogenesis, transmission, and evolution of influenza viruses; and characterize the protective immune response

Centers of Excellence for Influenza Research and Surveillance (CEIRS)

Diane Post, NIAID

Sequencing the complete influenza genome with rapid access of the genomic data through the NCBI GenBank and the Influenza Virus Resource, as well as the NIAID Influenza Research Database, one of the Bioinformatics Resource Centers. Bioinformatics analysis tools supported through the Influenza Research Database.

NIAID Influenza Genome Sequencing Project

Databases and Analysis Tools:
Influenza Research Database

NCBI Influenza Virus Resource

Maria Y. Giovanni, NIAID

Apply state-of-the-art high-throughput structural biology technologies to characterize the three dimensional (3-D) atomic structure of targeted proteins from pathogens in the NIAID Category A-C priority lists and organisms causing emerging and re-emerging infectious disease, including H1N1 influenza. Structural Genomics Centers for Infectious Diseases Valentina Di Francesco, NIAID
Conduct research projects to analyze, identify, quantify, model and predict the overall dynamics of the network of cellular molecular components of microbial organisms, including H5N1 influenza, and their interactions with the host cells. Systems Biology for Infectious Disease Research Valentina Di Francesco, NIAID
Generating the three-dimensional structures for influenza polymerase proteins and deposit structural data into public protein database. Proteomics Resource Center Maureen Beanan, NIAID
Provide reagents and information for studying influenza Microbiology and Infectious Diseases Biological Resources Repository Thames Pickett, NIAID

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Last Updated October 19, 2011