The Laboratory of Allergic Diseases (LAD) conducts basic, translational, and clinical research on anaphylaxis, allergic inflammation, and food allergy. Researchers in LAD seek to better understand the various immune system components that are involved in these processes. They work to identify events at the molecular level that trigger allergic reactions, including severe anaphylactic reactions, to understand their causes. LAD investigators’ ultimate aim is to discover new ways to diagnose and treat food allergies.
Using samples from mouse models and patients with food allergy, LAD investigators are studying molecules called cytokines, which are released by T cells in response to food allergens. LAD investigators have identified subpopulations of a type of T cell, termed a Th2 cell, which produces different combinations of these cytokines. These Th2 subpopulations are each associated with different forms of food allergy; either classic anaphylactic food allergy or eosinophil-associated gastrointestinal disorders, including eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EG). The investigators are determining if these different Th2 subpopulations cause these different types of food allergy. Current research is focused on understanding the cellular and molecular basis for these different Th2 subpopulations and how they contribute to food allergy.
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Last Updated October 06, 2010