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Granulomatosis With Polyangiitis

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Granulomatosis with polyangiitis (GPA), previously called Wegener's granulomatosis, is a rare disease in which blood vessels and other tissues become inflamed. This inflammation limits blood flow to important organs in the body, potentially leading to long-term damage. Disease onset and severity varies between patients, and earlier diagnosis and treatment can prevent life-threatening organ failure.

Although the disease can involve any organ system, GPA mainly affects the respiratory tract (sinuses, nose, trachea [windpipe], and lungs) and kidneys. This disorder can affect people at any age and strikes men and women equally. Compared to other racial groups, Caucasians are more commonly affected.

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Last Updated October 29, 2013