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Currently Active Grants (under RFAs and PAs only)

For information on any of the grants listed below, please use the National Institutes of Health (NIH) Research Portfolio Online Reporting Tools Expenditures and Results (RePORTER) system. RePORTER is an electronic tool that allows users to search for information on NIH-funded research projects.

Targeting Persistent HIV Reservoirs (TaPHIR) (PAR-12-109):

  • Persistent virus reservoirs in SIV-infected macaques, Mirko Paiardini
  • Targeting the persistent HIV-1 viral reservoir using engineered T cells, James Riley
  • Synthetic molecular sensors to target latently infected cells for HIV eradication, Christopher Woelk
  • Specific Killing of latently HIV-1-infected cells after provirus reactivation, Qigui Yu
  • A micro-co-culture assay for single-cell analysis of HIV Latency, Matthew Strain
  • HIV eradication by ADCC-activated NK cell killing, Jonathan Karn
  • Novel flow cytometry-based assay for HIV-infected cells, Joseph M. McCune
  • Targeting HIV Lung Reservoir in the Macaque Model, Marcelo Kuroda
  • Specific activation of latent HIV-1 by inhibiting E3 ubiquitin ligase activity, Joseph Dougherty
  • Killing the Reservoir with Antibodies, Galit Alter
  • Inhibiting Immune Evasion by HIV-1 Nef to Facilitate Eradication, John Guatelli
  • Cell-Based Secretion of Antiviral Molecules as a Treatment for HIV-AIDS, Hans-Peter Kiem
  • HIV-specific nucleases to reservoir cells, Paula Cannon
  • A family of compounds that reactivate latent HIV without T cell activation, Alberto Bosque
  • Modified CMV-specific T cells to Target HIV, Stephen Braun
  • Characterization of follicular dendritic cells as a reservoir for HIV, Michael Carroll
  • Lineage marking in humanized mice to reveal HIV-1 reservoirs, Benjamin Chen
  • Development of Nef antagonists to enhance CTL clearance of HIV reservoirs, Kathleen Collins
  • Novel small molecules to reactivate latent HIV and sensitize to anti-viral therapies, Ivan D’Orso and Elisabeth Martinez
  • Effective lethal agents for CCR5 expressing cells, Dennis Hartigan-O’Connor
  • Targeting latent HIV-1 Reservoirs with the Antibody-Drug Conjugate Brentuximab Vedotin, Timothy Henrich
  • Curing HIV Through Allogeneic Hematopoietic Stem Cell Transplantation, Leslie Kean
  • Targeting Macrophage Reservoirs in the Macaque Model of Pediatric AIDS, Marcelo Kuroda
  • Kinomic analysis of host cell factors controlling latent HIV-1 infection, Olaf Kutsch
  • Targeting Cytolytic Cells to Lymphoid Sites of HIV Persistence, Michael Lederman and Mirko Paiardini
  • Adipose Tissue is a significant reservoir for HIV, Dorothy Lewis and Ashok Balasubramanyam
  • An ex vivo model to predict outcomes and probe mechanism of anti-reservoir agents, Una O’Doherty
  • Role of P-TEFB in HIV latency, Andrew Rice
  • Alpha Emitter Labeled Anti-T Cell Antibody: Targeting Latent HIV Infected Cells, Brenda Sandmaier
  • Targeting SIV reservoirs with type I Interferons, Guido Silvestri
  • High throughput analysis of latency/reactivation with barcoded proviruses, Alice Telesnitsky, Cheong-Hee Chang, and Jeffrey Kidd
  • Purging the latent HIV reservoir at ART initiation: A new eradication strategy, Lydie Trautmann and Nicolas Chomont
  • Suppressing the latent reservoir with a Tat inhibitor, Susana Valente
  • Therapeutic vaccination targeting SIV viral reservoirs, Vaiva Vezys
  • Evaluating HIV expression and latency in blood and tissues at the single cell level, Joseph Wong
  • Targeting HIV-1 persistence with Interferon-alpha, Xu Yu
  • Cooperation of BRD4 and TAT Associated Proteins in HIV Transcription and Latency, Jian Zhu

Innovative Assays to Quantify the Latent HIV Reservoir (RFA-AI-13-038)

  • TILDA: A new sensitive and precise assay to measure the size of the latent HIV reservoir, Nicolas Chomont
  • A Novel Microfluidic HIV-1 Co-Culture Assay to Quantify Latent Reservoirs, Timothy Henrich
  • Nanotrap particle-based assay to quantify HIV-1 in latently-infected T cells, Fatah Kashanchi
  • New and Simple Assay to Measure Latent HIV Reservoir Using Deep Sequencing Method, Sook-Kyung Lee
  • Simplified Assays of Latent But Inducible HIV-1 Reservoirs, John Mellors
  • Novel methods for measuring the reservoir of inducible HIV-1 proviruses in resting CD4+ T cells, Janet Siliciano
  • Detection of Latent HIV Infection Using Selective Reaction Monitoring Mass Spectrometry, John Tilton

Basic Research on HIV Persistence (PA-12-161 and PA-12-162)

  • HIV Infection of Hematopoietic Progenitor Cells, Kathleen Collins
  • HIV-1 evolution in the female genital tract and trafficking to the blood, Lisa Frenkel
  • Identification and eradication of HIV tissue reservoirs in a relevant animal model, Binhua Ling
  • A Microengraving Technology for the Study of Latently HIV-infected Primary Cells, Xu Yu
  • Targeting HIV Reservoirs in vitro and in vivo, Jerome Zack
  • Tat cofactors and control of HIV-1 latency, Qiang Zhou
  • Role of Gut Associated Lymphoid Tissue in HIV Persistence, Joseph Wong
  • An ex vivo Model of HIV-1 Latency and Reactivation Using Primary Memory Cells, Vicente Planelles
  • Phenotypic Analysis of Latently Infected CD4+ T Cells, Joel Blankson
  • Reactivation of Latent HIV through TLR Signaling, Alberto Bosque
  • Quantifying the Effect of HIV Latency, Thomas Leitner
  • Limiting HIV-1 Persistence by Targeting Stem Cell Properties of CD4 T Cells, Mathias Lichterfeld
  • Novel Mechanisms for Coreceptor Switching, Donald Mosier
  • Heat Shock Protein 90 and HIV Persistence, Cheryl Stoddart
  • P-TEFb and HIV Latency, Andrew Rice

Martin Delaney Collaboratory: Towards an HIV Cure (RFA-AI-10-009)

  • Targeted Modification of Host and Proviral DNA to Treat Latent HIV Infection, Keith Jerome and Hans-Peter Kiem
  • Martin Delaney Collaboratory to Eradicate HIV-1 Infection, David Margolis
  • DARE: Delaney AIDS Research Enterprise to Find a Cure; Steven Deeks, J. Michael McCune, and Rafick Sekaly

For current information on collaboratory research, visit the following websites:

Beyond HAART:  Innovative Therapies to Control HIV-1 (RFA-AI-11-012)

  • A Gene Therapeutic Approach to Stable Suppression of HIV-1 Replication, Michael Farzan
  • RNA directed silencing and excision of HIV-1 and CCR5, Kevin Morris

Delivering Therapeutics to Residual Active HIV Reservoirs (RFA-AI-12-042)

  • Plug and Purge: In Vivo Targeting of Active HIV Reservoirs That Persist Despite ART, Victor Garcia-Martinez
  • T-cell-mediated targeting of therapeutics to HIV reservoirs, Darrell Irvine
  • Multi-Species Mechanisms of Drug Bio-distribution in HIV Tissue Reservoirs, Angela Kashuba
  • Mechanisms of Formation and Persistence of Active HIV Reservoirs, James Mullins
  • Targeted inhibition of HIV-1 latency, Kevin Morris
  • Monitoring SIV reservoirs with whole body immunoPET, Francois Villinger and Philip Santangelo
  • Also in this section, after Darrell Irvine’s name add “and Bruce Walker” since this is multi-PI

Ethical Issues in Research in HIV/AIDS and its Co-morbidities

  • Unintended and Intended Implications of HIV Cure: A Social and Ethical Analysis, Joseph Tucker

Last Updated April 14, 2014