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Leading research to understand, treat, and prevent infectious, immunologic, and allergic diseases
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HIV/AIDS Prevention Research

With the goal of achieving an “AIDS-Free Generation,” the NIAID priority for HIV prevention research is to develop and test safe, effective, and acceptable biomedical and behavioral HIV prevention products and interventions that will help halt the spread of HIV infection globally. NIAID prevention research encompasses the development and testing of vaccines, new and improved combination prevention strategies, microbicides, treatment as prevention (TasP), and pre-exposure prophylaxis (PrEP). Underlying these efforts is behavioral and social science research to understand and address factors affecting the adoption and acceptance of any given approach.

NIAID-funded research has already led to the identification of highly effective non-vaccine prevention strategies that have the potential to significantly reduce HIV infection rates around the world. To improve upon these and develop additional strategies, NIAID non-vaccine prevention efforts seek to 

  • Create and sustain a pipeline that advances sustained delivery systems and promising candidates, including combination prevention products for HIV, sexually transmitted diseases and contraceptives; microbicides; PrEP; and immune-based products for prevention
  • Focus on approaches for specific populations (e.g., men who have sex with men,  transgender individuals, pregnant or lactating women, children and adolescents, and men of color)
  • Advance HIV prevention trial methodologies to efficiently assess products and determine the community-level impact of integrated prevention strategies
  • Optimize the testing, linkage to care, and treatment cascade
  • Support development of optimized, cost-efficient, point-of-care HIV incidence assays
  • Strengthen partnerships with community groups, scientific investigators, and other organizations globally
  • Support mathematical modeling and testing of integrated HIV prevention strategies to reduce HIV incidence, focusing on effectiveness, feasibility and sustainability, acceptability in the target population, and cost effectiveness

Key Prevention Research Areas

Last Updated January 27, 2016