DNA vaccines represent a favored vaccine strategy because they are safe, stable, easy to engineer and produce, and immune responses generated pose no interference against later boost immunizations. However, DNA vaccines need to be improved significantly as they do not induce sufficient levels of immune responses in humans and non-human primates.
Strategies for enhancing DNA vaccines include improving gene expression and delivery methods, and adding molecular adjuvants:
Outside of clinical trials, no DNA vaccines have yet been approved for use in humans by the Food and Drug Administration, the U.S. regulatory agency responsible for ensuring safety of food, drugs and medical devices.
View the FDA guidance on DNA vaccines.
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Last Updated January 14, 2010