The SVEU contracts serve as a resource to evaluate promising SIV and HIV vaccines in nonhuman primates in support of HIV vaccine development.
Proposals from investigators for vaccine studies are evaluated by NIAID and approved studies are conducted at one of the three SVEU contract sites. SVEUs conduct collaborative studies in which the vaccine investigator works together with the SVEU Principal Investigator and the SVEU Project Officer on the study design and data evaluation.
The SVEU provides the nonhuman primates for studies to evaluate candidate SIV or HIV vaccines. The SVEU contractor will immunize nonhuman primates with the candidate vaccine and together with the Primate Immunology Laboratory, can evaluate humoral and cellular immune responses. The SVEU can also challenge the animals with SIV or SHIV virus, can determine the levels of replicating virus post-challenge, and will evaluate disease outcomes.
The SVEUs conduct several types of studies:
Advanced BioScience LaboratoriesKensington, MarylandDr. Ranajit Pal
BioqualRockville, MarylandP.I.: Dr. Mark Lewis
Tulane UniversityCovington, LouisianaP.I.: Dr. Andrew Lackner
Cellular Immune AssaysBeth Israel HospitalBoston, MassachusettsDr. Norman Letvin
Virus Neutralization AssaysDuke UniversityDurham, North CarolinaDr. David Montefiori
Advanced BioSciences LaboratoriesKensington, MarylandDr. Ranajit Pal
Dr. Nancy MillerDivision of AIDS, Preclinical Research and Development BranchPhone: 301-435-3753Email: firstname.lastname@example.org
Dr. Jon WarrenDivision of AIDS, Preclinical Research and Development BranchPhone: 301-402-0633Email: email@example.com
Dr. Yen LiDivision of AIDS, Preclinical Research and Development BranchPhone: 301-496-3816Email: firstname.lastname@example.org
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Last Updated November 14, 2013