You can help researchers improve public health by volunteering for NIAID clinical studies.
CGD is an inherited syndrome in which white blood cells called phagocytes are unable to kill certain bacteria and fungi. People with CGD have increased susceptibility to infections caused by certain types of bacteria and fungi. Some examples of these types of bacteria include the following:
And here are the fungi related to CGD:
CGD is caused by defects in an enzyme that phagocytes need to kill bacteria and fungi. Mutations in one of five different genes can cause this defect, which leads to frequent and sometimes life-threatening infections of the skin, lungs, and bones with swollen collections of inflammatory cells called abscesses (boils) or granulomas (inflamed masses of tissue).
CGD may be suspected in children or adults with the following symptoms:
In some people, granulomas can cause inflammatory bowel disease that looks a lot like Crohn’s Disease.
CGD is diagnosed by special blood tests that show how well phagocytes produce hydrogen peroxide.
The key to managing CGD is early diagnosis and treatment with appropriate antibiotics. The goal is to prevent infections and their aftermath.
Last Updated October 20, 2010
Last Reviewed October 14, 2010