You can help researchers improve public health by volunteering for NIAID clinical studies.
People with CVID have low levels of immunoglobulin (antibodies) and an increased risk for infection. Although the disease is usually diagnosed in adults, it can also occur in children.
CVID is also known by the following names:
Click on the topics below to view more information.
Research has shown that CVID is more common in families with immunoglobulin A (IgA) deficiency; however, the causes of CVID have not been identified in more than 90 percent of cases.
Read about the gene linked to CVID.
Signs and symptoms
Most people with CVID have frequent bacterial infections of the ears, sinuses, and lungs.
Some people also may have symptoms such as the following:
Doctors can diagnose CVID by weighing several factors:
People with CVID receive intravenous (through the vein) immunoglobulin every 3 to 4 weeks or subcutaneous (just under the skin) immunoglobulin weekly to restore normal antibody levels. The immunoglobulin given by either of these methods provides antibodies from about 60,000 healthy donors each time it is given. Bacterial infections are treated with antibiotics. Many patients need preventive antibiotics as well.
Last Updated July 17, 2012
Last Reviewed October 14, 2010