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Primary Immune Deficiency Diseases

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Hyper-Immunoglobulin M (Hyper-IgM) Syndrome

micrograph of lung tissue with cysts
Section of lung tissue (green) with Pneumocystis jiroveci cysts (dark spheres) stained with methenamine silver stain.
Credit: CDC Public Health Image Library, ID#960

Hyper-IgM syndromes are conditions in which the immune system fails to produce normal immunoglobulin A (IgA), IgG, and IgE antibodies but can produce normal or elevated IgM.

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Signs and symptoms





Last Updated July 17, 2012

Last Reviewed October 14, 2010