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Primary Immune Deficiency Diseases

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Hyper-Immunoglobulin E Syndrome (HIES) or Job’s Syndrome

artwork of Job with boils
Folio 46r from the Syriac Bible of Paris depicting the biblical character Job suffering from boils. Credit: Wikimedia Commons

People with HIES have recurrent staphylococcal abscesses (boils) of the skin and lungs. They also have an itchy skin rash (eczema), very high levels of a type of antibody called immunoglobulin E (IgE), and a tendency to have bone fractures.

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Last Updated July 17, 2012

Last Reviewed October 14, 2010