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Primary Immune Deficiency Diseases

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Leukocyte Adhesion Deficiency (LAD)

diagram of CD18 protein
Crystal structure of the protein CD18 (ribbon diagram). Reference: Protein Data Bank, DOI: 10.2210/pdb1L3Y/pdb

LAD is an immune deficiency in which phagocytes are not able to migrate to the site of infection to fight off invading germs. This inability to fight germs results in recurrent, life-threatening infections and poor wound healing. LAD is an autosomal recessive disease (disease caused when two copies of the abnormal gene are present).

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Last Updated July 17, 2012

Last Reviewed October 14, 2010