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Primary Immune Deficiency Diseases

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Severe Combined Immunodeficiency (SCID)

SCID is a syndrome caused by mutations in at least 13 different genes. In this condition, there is a complete absence of B- and T-cell function. Until approximately 30 years ago, SCID was fatal within the first year or two of life. It is inherited as either an X-linked (disease caused by genes located on the X chromosome) or an autosomal recessive (disease caused when two copies of the abnormal gene are present) defect.

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Last Updated July 17, 2012

Last Reviewed October 14, 2010