Volunteer for NIAID-funded clinical studies related to immune tolerance on ClinicalTrials.gov.
The immune system is precisely tuned to distinguish biochemical structures that belong to the body from those that do not, allowing it to swiftly deploy a potent array of defense mechanisms whenever evidence of a foreign invasion is found. However, many conditions, including autoimmune disorders, allergic diseases, and transplant rejection, are caused by inappropriate immune system responses. To fight these disorders, researchers are now building on two decades of intensive basic research in immunology to develop treatments that can induce the immune system to tolerate specific antigens. Progress in the development of these therapies, which have the potential to be both very potent and broadly applicable, has been very encouraging.
All tolerance-induction strategies share a common goal: to selectively prevent or diminish specific harmful immune responses without disabling the immune system as a whole.
Last Updated March 28, 2006