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Additional Information From NIAID

Immune Tolerance

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The Immune Tolerance Network, an international research consortium sponsored by NIAID, conducts clinical trials to evaluate new approaches to preventing organ transplant rejection. Credit: National Kidney Foundation, 2010 U.S. Transplant Games

The immune system is precisely tuned to distinguish biochemical structures that belong to the body from those that do not, allowing it to swiftly deploy a potent array of defense mechanisms whenever evidence of a foreign invasion is found. However, many conditions, including autoimmune disorders, allergic diseases, and transplant rejection, are caused by inappropriate immune system responses.

To fight these disorders, researchers are now building on two decades of intensive basic research in immunology to develop treatments that can induce the immune system to tolerate specific antigens.

Progress in the development of these therapies, which have the potential to be both very potent and broadly applicable, has been very encouraging.

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Strategies

 

Research Activities

 

Clinical Studies

 

 

Research Plan

Foreword

 

Report of the NIAID Expert Panel on Immune Tolerance

 

Recommendations of the NIAID Expert Panel on Ethical Issues in Clinical Trials of Transplant Tolerance

 

Part 1: Overview

 

Part 2: Background

 

Part 3: Detailed Research Plan
A: Transplantation

 

Part 3: Detailed Research Plan
B: Autoimmune Diseases

 

Part 3: Detailed Research Plan
C: Asthma and Allergic Diseases

 

Part 3: Detailed Research Plan
D: Cross-Cutting Research

Last Updated September 30, 2013

Last Reviewed October 18, 2010