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The symptoms of systemic lupus erythematosus (SLE) vary widely. SLE often mimics or is mistaken for other illnesses because the symptoms come and go unpredictably. Diagnosis can be elusive, with patients sometimes suffering unexplained symptoms and untreated SLE for years. Common initial and chronic complaints are fever, malaise, joint pains, fatigue, and temporary loss of cognitive abilities.

Last Updated February 25, 2009

Last Reviewed February 25, 2009