Mastocytosis

Research

NIAID scientists have studied and treated patients with mastocytosis for more than three decades at the National Institutes of Health (NIH) Clinical Center.

Some of the most important research advances for this rare disorder include:

• Improved diagnosis of mast cell disease
• Identification of growth factors responsible for increased mast cell production
• Improved treatment

For example, researchers have developed drugs that help block the division of mast cells and the action of chemicals released from mast cells.

Scientists also are focusing on identifying gene mutations associated with the disease. Several such mutations have been identified at NIH in a cell receptor for a mast cell growth factor and in key molecules within mast cells that control cell activation. Understanding such mutations helps researchers understand the causes of mastocytosis, improve diagnosis, and develop better treatment.