NIAID-supported scientists are examining the 2009 H1N1 virus and other seasonal influenza viruses on a molecular level to learn more about their origin, evolution, and pathogenesis—knowledge that may be critical to curbing the impact of the current and possible future pandemics.
The goal of the NIAID Influenza Virus Sequencing Project is to sequence the complete genome of thousands of circulating influenza viruses, including the 2009 H1N1 strain. The genomic and associated clinical data will be made rapidly available to the scientific community to help them to answer critical questions, such as whether the 2009 H1N1 virus is changing or if it is interacting with other circulating viruses. Influenza sequencing is being generated through the NIAID-funded Genome Sequencing Center (GSC) at the J. Craig Venter Institute (JCVI). JCVI has the capacity to sequence hundreds of viruses per week using next generation sequencing technologies. To date, NIAID has sequenced more than 9,300 viruses.
The NIAID-funded Influenza Research Database (IRD) provides the scientific community with influenza sequence data and bioinformatic tools in a user-friendly format and includes data on the 2009 H1N1 strain. The site provides additional information such as phylogenetic trees, phenotypic markers for drug resistance and virulence, and immunological, experimental, and clinical data.
NIAID is also supporting advanced technologies to enhance molecular knowledge of influenza viruses. For example, scientists supported through the NIAID Immune Epitope Database and Analysis Resource contract have conducted a 2009 H1N1 flu epitope analysis. In addition, the Structural Genomics Centers for Infectious Diseases are using state-of-the-art technologies to characterize the three-dimensional atomic structure of targeted proteins from influenza viruses, including 2009 H1N1 influenza. Such analysis provides crucial knowledge about how influenza viruses interact with the human immune system.
The NIAID-funded Pathogen Functional Genomics Resource Center, at JCVI, has made more than two dozen Gateway Entry Clones from two 2009 H1N1 Influenza A strains available free of charge to researchers. The clones are valuable resources for researchers evaluating processes such as viral protein expression and processing. For more information on the NIAID H1N1 genomics and advanced technology resources, please see
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Last Updated July 10, 2012