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Genomics and Advanced Technologies

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Pathogen Genomics and Related Initiatives

Please note that the information on this page is not intended as a complete list of NIAID advanced technologies initiatives. For more information, please see the NIAID Research Funding and Resources for Researchers sections.

Bioinformatics Resource Centers

The Bioinformatics Resource Centers (BRCs) provide scientists with genomic and related data for NIAID Category A–C pathogens, pathogens causing emerging and re-emerging infectious diseases, and invertebrate vectors of infectious diseases. The BRCs will integrate diverse research data types, to include genomics sequence data, functional genomics and proteomics data, host/pathogen interactions, epidemiology, phenotypes to clinical isolates and associated metadata, to be collected from public data repositories and/or generated by other initiatives funded by NIAID.

For more information, contact Dr. Alison Yao.

Clinical Proteomics Centers for Infectious Diseases and Biodefense

The NIAID Clinical Proteomics Centers apply state-of-the-art proteomics technologies for the discovery, qualification, and verification of protein biomarkers in well-defined clinical samples collected for infectious diseases caused by NIAID Category A–C pathogens and emerging and re-emerging infectious diseases.

Members of the scientific community may request proteomic technology and expertise from the Centers.

For more information, contact Valentina Di Francesco.

Genomics Centers for Infectious Diseases

The Genomic Centers for Infectious Diseases provide services for rapid and cost-efficient production of high-quality, genome sequences and high-throughput genotyping of NIAID Category A–C priority pathogens, related organisms, clinical isolates, closely related species, invertebrate vectors of infectious diseases, and microorganisms responsible for emerging and re-emerging infectious diseases and their hosts.

Members of the scientific community may request microbial genome sequencing as well as human and microbial genotyping services.

For more information, contact Dr. Maria Y. Giovanni.

Influenza Research Database

The Influenza Research Database is an integrated data and analysis resource for influenza researchers that includes genomic, clinical, experimental epitope, surveillance, virulence, transmission, and host range data. The resource allows users to search, download, annotate, display, and analyze influenza virus research data.

For more information, contact Dr. Alison Yao.

Structural Genomics Centers for Infectious Diseases

The two Structural Genomics Centers experimentally characterize the three-dimensional atomic structure of targeted proteins using state-of-the art, high throughput structural biology technologies. Proteins will be chosen from pathogens in the NIAID Category A–C pathogens and organisms causing emerging and re-emerging diseases.

Members of the scientific community may request the determination of 3-D protein structures. Sequence-verified clones are also available through the centers.

For more information, contact Valentina Di Francesco.

Systems Biology for Infectious Diseases Research

The five systems biology centers are using a combination of computational and experimental methodologies to analyze, identify, quantify, model, and predict the overall dynamics of microbial organisms’ molecular networks, including their host interactions.

For more information, contact Valentina Di Francesco.

 

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Last Updated May 08, 2013