New NIAID Radiation and Nuclear Countermeasures Program’s DAIT Council-Approved Research Concepts (January 27, 2014)
BAA-13-100-SOL-00013: Advanced Research and Development of Chemical, Biological, Radiological, and Nuclear Medical Countermeasures for BARDA. Posted July 31, 2013
BAA-13-100-SOL-00014: Science and Technology Platforms Applied to Medical Countermeasure Development (Innovations) for BARDA. Posted July 31, 2013
Satyamitra M, Lombardini E, Peng T, Devore D, Graves J, Mullaney C, Ney P and Srinivasan V. Preliminary nonclinical toxicity, pharmacokinetics, and pharmacodynamics of ALXN4100TPO, a thrombopoietin receptor agonist, in CD2F1 mice. Int J Toxicol. 2013,32: 100-112.
Moroni M, Ngudiankama BF, Christensen C, Olsen CH, Owens R, Lombardini ED, Holt RK, Whitnall MH. The Gottingen minipig is a model of the hematopoietic acute radiation syndrome: G-colony stimulating factor stimulates hematopoiesis and enhances survival from lethal total-body γ-irradiation. Int J Radiat Oncol Biol Phys. 2013 Aug 1;86(5):986-92.
Cary L, Ngudiankama B, Salber R, Ledney D, Whitnall M. Efficacy of Radiation Countermeasures Depends on Radiation Quality. Radiat Res. 2012 May;177(5):663-75.
Singh V, Ducey E, Fatanmi O, Singh P, Brown D, Purmal A et al. CBLB613: A TLR 2/6 Agonist, Natural Lipopeptide of Mycoplasma arginini, as a Novel Radiation Countermeasure. Radiat Res. 2012 May; 177(5): 628–642.
Grace M, Singh V, Rhee J, Jackson W, Kao T, Whitnall M. 5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis. Radiat Res. 2012; [Epub].
Fukumoto R, Kiang JG. Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation. Radiat Res. 2011 Sep;176(3):333-45.
Moroni M, Lombardini E, Salber R, Kazemzedeh M, Nagy V, Olsen C, Whitnall MH. Hematological changes as prognostic indicators of survival: similarities between gottingen minipigs, humans, and other large animal models. PLoS One. 2011;6(9):e25210. Epub 2011 Sep 28.
Moroni M, Coolbaugh TV, Lombardini E, Mitchell JM, Moccia KD, Shelton LJ, Nagy V, Whitnall MH. Hematopoietic radiation syndrome in the Gottingen minipig. Radiat Res. 2011;176:89–101.
Moroni M, Coolbaugh TV, Lombardini E, Mitchell JM, Moccia KD, Nagy V, Whitnall MH. Vascular access port implantation and serial blood sampling in a Gottingen minipig (Sus scrofa domestica) model of acute radiation injury. J Am Assoc Lab Anim Sci. 2011;50: 65-72.
Satyamitra MM, Lombardini E, Graves J, Mullaney C, Ney P, Hunter J, Johnson K, Tamburini P, Wang Y, Springhorn JP, Srinivasan V. A TPO receptor agonist, ALXN4100TPO, mitigates radiation-Induced lethality and stimulates hematopoiesis in CD2F1 mice. Radiat Res. 2011;175(6):746-758.
Satyamitra MM, Kulkarni S, Ghosh S, Conor P, Mullaney CP, Condliffe D, Srinivasan V. Hematopoietic recovery and amelioration of radiation-induced lethality by the vitamin E isoform d-Tocotrienol. Radiat Res. 2011;175(6):736-745.
Romm H, Wilkins RC, Coleman CN, Lillis-Hearne PK, Pellmar TC, Livingston GK, Awa AA, Jenkins MS, Yoshida MA, Oestreicher U, and Prasanna PGS. Biological dosimetry by the triage dicentric chromosome assay: potential implications for treatment of acute radiation syndrome in radiological mass casualties radiation research. Radiat Res. 2011 Mar;175(3):397-404.
Li XH, Fu D, Latif NH, Mullaney CP, Ney PH, Mog SR, Whitnall MH, Srinivasan V, Xiao M. Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. Haematologica. 2010 Dec;95(12):1996-2004.
Gorbunov NV, Garrison BR, Kiang JG. Response of crypt paneth cells in the small intestine following total-body gamma-irradiation. Int J Immunopathol Pharmacol. 2010 Oct-Dec;23(4):1111-23.
Kulkarni S, Ghosh S, Satyamitra M, Mog S, Hieber K, Romanyukha L, Gambles K, Toles R, Kao T, Hauer-Jensen M, and Kumar K. Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation. Radiat Res. 2010; 173(6):738-747.
Kiang J, Jiao W, Cary L, Mog S, Elliott T, Pellmar T and Ledney G. Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection. Radiat Res. 2010;173(3):319-32.
Ledney GD, Elliott TB. Combined injury: factors with potential to impact radiation dose assessments. Health Phys. 2010;98(2):145-52.
Prasanna PG, Blakely WF, Bertho JM, Chute JP, Cohen EP, Goans RE, Grace MB, Lillis-Hearne PK, Lloyd DC, Lutgens LC, Meineke V, Ossetrova NI, Romanyukha A, Saba JD, Weisdorf DJ, Wojcik A, Yukihara EG, Pellmar TC. Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop. Radiat Res.2010;173(2):245-253.
Jiao W, Kiang JG, Cary L, Elliott TB, Pellmar TC, Ledney GD. COX-2 inhibitors are contraindicated for treatment of combined injury. Radiat Res. 2009;172(6):686-97.
Prasanna PGS, Moroni M, and Pellmar TC. Triage dose assessment for partial-body exposure: Dicentric analysis. Health Phys. 2010;98(2):244-51.
Gorbunov N and Kiang J. Up-regulation of autophagy in small intestine Paneth cells in response to total-body γ –irradiation. J Pathol. 2009; 219: 242–252.
Kiang J, Smith J and Agravante N. Geldanamycin analog 17-DMAG inhibits iNOS and caspases in gamma-irradiated human T cells. Radiat Res. 2009;172:321–330.
Pathak R, Ramakumar A, Subramanian U, Prasanna P. Differential radio-sensitivities of human chromosomes 1 and 2 in one donor in interphase and metaphase–spreads after 60Co γ-irradiation. BMC Med Phys. 2009;9:6.
Wilkins RC, Romm H, Kao TC, Awa AA, Yoshida MA, Livingston GK, Jenkins MS, Oestreicher U, Pellmar TC, Prasanna PG. Interlaboratory comparison of the dicentric chromosome assay for radiation biodosimetry in mass casualty events. Radiat Res. 2008;169(5):551-60.
Srinivasan V; Doctrow S, Singh V, Whitnall M. Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 2008; 30:271–290.
Satyamitra MM, Ghosh SP, Srinivasan V. Chemoprevention, Radiotherapy and Radioprotection by Tocotrienols from Palm Oil Extracts and Flavonoids Isolated from Ocimum sanctum (Tulasi). In: Herbal Drugs: A Cancer Chemopreventive and Therapeutic Perspective. New Delhi: Jaypee Brothers Medical Publishers Pvt Ltd, 2010 [no PubMed abstract available].
Martin P, Berdychevski R, Subramanian U, Blakely W, and Prasanna P. Sample tracking in an automated cytogenetic biodosimetry laboratory for radiation mass casualties. Radiat Meas. 2007; 42(6-7):1119–1124.
Xiao M, Inal C, Parekh V, Chang C and Whitnall M. 5-Androstenediol promotes survival of gamma-irradiated human hematopoietic progenitors through induction of NF-kappa B activation and G-CSF expression. Mol Pharmacol. 2007; 72(2):370-9.
Walchuk M and Roessler G. Cytogenetic biodosimetry at the Armed Forces Radiobiology Research Institute. Health Phys News, 2007; 35:11 [no PubMed abstract available].
Last Updated October 11, 2012
Last Reviewed October 18, 2011